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DTSTART;TZID=America/New_York:20190315T140000
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DTSTAMP:20190315T125910Z
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SUMMARY:PICS Seminar: "Coupled Multiphysics Models of Cardiac Hemodynamics: From Fundamental Insights to Clinical Translation"
DESCRIPTION: \n\n\nAbstract: The mammalian heart has been sculpted by millions of years of evolution into a flow pump par excellence. During the typical lifetime of a human\, the heart will beat over three billion times and pump enough blood to fill over 60 Olympic-sized swimming pools. Each of these billions of cardiac cycles is itself a manifestation of a complex and elegant interplay between several distinct physical domains including electrophysiology and mechanics of the cardiac muscles\, hemodynamics\, and flow-induced movement of the cardiac valves. Another multiphysics interaction that is key to hemostasis involves hemodynamics and blood biochemistry. The clotting cascade\, which is a natural response to injury\, is initiated by a sequence of biochemical reactions that are strongly modulated by the local flow conditions. In this regard\, how the chambers and valves of a healthy heart manage to avoid thrombosis\, remains an open question. The presence of heart conditions such as myocadial infarction (MI)\, cardiomyopathies\, valve anomalies and atrial fibrillations\, disturb the hemostatic balance and can lead to thrombosis with devastating sequalae such as stroke and MI. Computational models for thrombogenesis in the cardiac system have the potential to provide useful insights into this important phenomenon. In the current talk\, I will describe high-fidelity chemo-fluidic modeling of thrombogenesis in the left heart and demonstrate how fundamental insights from these studies are translated into clinically relevant metrics. Application of these models to thrombogenesis in transcatheter aortic valves will also be described.
URL:https://seasevents.nmsdev7.com/event/pics-colloquium-coupled-multiphysics-models-of-cardiac-hemodynamics-from-fundamental-insights-to-clinical-translation/
LOCATION:Room 401B\, 3401 Walnut\, 3401 Walnut Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Colloquium
ORGANIZER;CN="Penn Institute for Computational Science (PICS)":MAILTO:dkparks@seas.upenn.edu
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