The study of the early universe requires deep high-resolution maps of the sky at millimeter and submillimeter. This requires the development of state-of-the-art cryogenic receivers and custom built telescopes. These instruments operate in extreme locations including from NASA launched high-altitude balloons over Antarctica and high (5,200m/17,000ft) mountain tops in Northern Chile adding a level of planning and complexity beyond what is normally required for astronomical observations. I will discuss the science goals of these instruments and how we develop instruments at Penn to meet these goals.