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SUMMARY:MEAM Seminar: "Cell Polarization and Growth"
DESCRIPTION:Polarization is an essential behavior of living cells\, yet the dynamics of this symmetry-breaking process are not fully understood. We have developed a spatial stochastic model of cellular polarization during mating of Saccharomyces cerevisiae. Specifically we investigated the ability of yeast cells to sense a spatial gradient of mating pheromone and respond by forming a projection in the direction of the mating partner. Our results demonstrate that a spatial stochastic model of polarisome formation can more robustly reproduce two fundamental characteristics observed in wild-type cells: a tightly polarized phenotype and the ability to track moving pheromone input\, in comparison with the corresponding deterministic model. \nExisting models of cell polarization have focused solely on the biochemical signaling system. However\, there exists a well-known interplay between the growth of the mating projection and the mechanical forces of the cell wall in determining the shape of the cell. The cell wall of S. cerevisiae both defines its shape and provides the mechanical integrity necessary to sustain the large internal turgor pressure. Under the isotropic push of turgor pressure\, polarized expansion occurs via localized assembly of new cell wall material in combination with a simultaneous softening of the cell wall\, inducing it to yield and locally expand. Intracellular signaling directs enzymes with the ability to modify cross-linking of polymers in the cell wall to the region of polarization. The resulting mechanical feedback from the wall expansion initiates the delivery of raw material via vesicular transport. \nTo accurately model this complex biological phenomena\, we have developed a multiscale computational framework for simulating the coupling of the stochastic dynamics of biochemical reactions involved in shaping walled cells to the mechanical processes of cell wall expansion and growth. Our computational method exploits the time-scale separation between the relatively slow dynamics of the cell wall and the rapid interactions of the intercellular signaling network.
URL:https://seasevents.nmsdev7.com/event/meam-seminar-cell-polarization-and-growth/
LOCATION:Wu and Chen Auditorium (Room 101)\, Levine Hall\, 3330 Walnut Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Seminar
ORGANIZER;CN="Mechanical Engineering and Applied Mechanics":MAILTO:meam@seas.upenn.edu
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