This presentation will discuss the concept of BIGHEART and present various illustrative examples of this approach. The initial focus will be on NOAS (Nanoscale Optical Antennas) within the context of quantitative life sciences and transformative medicine. NOAS facilitates the visualization of quantum biological electron transfer processes occurring in mitochondria within living cells, supports the precise release of siRNAs with accurate spatiotemporal control, enables the detection of oscillatory communication among living bacteria via extracellular vesicles, and innovates ultrafast photonic PCR technology for enhanced precision in preventive medicine. EXODUS (Exosome Detection via the Ultrafast-Purification System) is meticulously designed to facilitate accurate diagnostics and therapeutic applications through the utilization of exosomes. The effective purification of exosomes from patients’ liquid biopsies enables comprehensive analyses and the advancement of translational medical treatments. iTEARS (Integrated Tear Exosome Analysis via Rapid-Isolation System) allows the detection of protein and miRNA biomarkers, thereby enhancing the diagnostic capability of various diseases through the analysis of tear samples. BOAS (Brain Organoid Analysis System), which integrates biosensors and EEG for real-time, non-invasive monitoring of brainwaves and extracellular vesicles (EVs), was developed to explore the connections between molecular signals and neurophysiological brainwaves. This study critically analyzes and offers insights into the interrelationships among secretomes, electrophysiological brainwaves, and the networks generated from human brain organoids. The in vitro models of BOAS serve as valuable tools for researchers investigating neuropathogenesis, developing treatments for neurodegenerative diseases, and exploring preventive medical therapies by studying the interactions between EVs and brainwaves. Furthermore, the BIGHEART initiative endeavors to create solutions for preventive and personalized medicine that contribute to affordable global healthcare.