BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Penn Engineering Events - ECPv6.15.18//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Penn Engineering Events
X-ORIGINAL-URL:https://seasevents.nmsdev7.com
X-WR-CALDESC:Events for Penn Engineering Events
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/New_York
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20190310T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20191103T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20200308T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20201101T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20210314T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20211107T060000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20201217T100000
DTEND;TZID=America/New_York:20201217T110000
DTSTAMP:20260407T074442
CREATED:20201201T181615Z
LAST-MODIFIED:20201201T181615Z
UID:3708-1608199200-1608202800@seasevents.nmsdev7.com
SUMMARY:MEAM Ph.D. Thesis Defense: "Structural and Mechanical Responses to Intermittent Parathyroid Hormone Treatment\, Discontinuation\, and Cyclic Administration Regimens"
DESCRIPTION:Bone mineral density rapidly decreases upon withdrawal from intermittent parathyroid hormone (PTH) treatment despite its potent effect of promoting bone formation. To better understand this adverse phenomenon\, this study first aimed to investigate the phenotype of PTH withdrawal in both intact and estrogen-deficient rat model by using a well-designed experiment combined with innovative longitudinal imaging techniques and localized cellular activities. Due to observing a continuous anabolic window upon early discontinuation of PTH treatment in estrogen-deficient animals\, we propose a potential effective treatment strategy\, the short cycles of PTH and antiresorptive treatment regimen\, which could extend the anabolic windows by increasing the number of newly activated modeling-based bone formation (MBF) sites. Lastly\, to understand the structure-function relationships of bone tissue formed through MBF compared to the remodeling-based bone formation (RBF)\, we developed an innovative imaging platform with a mechanical testing platform to determine the mechanical properties of MBF and RBF and their long-term contributions in intact animals.
URL:https://seasevents.nmsdev7.com/event/meam-ph-d-thesis-defense-discontinuation-of-intermittent-parathyroid-hormone-and-potential-osteoporosis-treatment-strategy/
LOCATION:Zoom – Email MEAM for Link\, peterlit@seas.upenn.edu
CATEGORIES:Seminar,Dissertation or Thesis Defense
ORGANIZER;CN="Mechanical Engineering and Applied Mechanics":MAILTO:meam@seas.upenn.edu
END:VEVENT
END:VCALENDAR