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SUMMARY:Immunology/BE Seminar: “Engineering Next-Generation CAR-T Cells for Cancer Immunotherapy” (Yvonne Chen)
DESCRIPTION:This event is part of the Penn Institute for Immunology Colloquium seminar series and is co-hosted by the Department of Bioengineering. This virtual event will be held on Bluejeans. \nAttend the live seminar via this link. Or download the Bluejeans app and and enter ID: wxbzgity \nContact ifiadmin@pennmedicine.upenn.edu with any questions. \nThe adoptive transfer of T cells expressing chimeric antigen receptors (CARs) has demonstrated clinical efficacy in the treatment of advanced cancers\, with anti-CD19 CAR-T cells achieving up to 90% complete remission among patients with relapsed B-cell malignancies. However\, challenges such as antigen escape and immunosuppression limit the long-term efficacy of adoptive T-cell therapy. Here\, I will discuss the development of next-generation T cells that can target multiple cancer antigens and resist immunosuppression\, thereby increasing the robustness of therapeutic T cells against tumor defense mechanisms. Specifically\, I will discuss the development of multi-input receptors and T cells that can interrogate intracellular antigens. I will also discuss the engineering of T cells that can effectively convert TGF-beta from a potent immunosuppressive cytokine into a T-cell stimulant. This presentation will highlight the potential of synthetic biology in generating novel mammalian cell systems with multifunctional outputs for therapeutic applications.
URL:https://seasevents.nmsdev7.com/event/immunology-be-seminar-engineering-next-generation-car-t-cells-for-cancer-immunotherapy/
CATEGORIES:Seminar,Colloquium
ORGANIZER;CN="Bioengineering":MAILTO:be@seas.upenn.edu
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