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DTSTART;TZID=America/New_York:20221121T100000
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DTSTAMP:20260405T121011
CREATED:20221115T163342Z
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UID:7899-1669024800-1669032000@seasevents.nmsdev7.com
SUMMARY:Dissertation Defense: Jingyu Wu
DESCRIPTION:LARGE-SCALE MICROFLUIDIC MANUFACTURING OF GRANULAR HYDROGELS AND MULTIPLE EMULSIONS \nAbstract: \nDroplet microfluidics have made tremendous progress in the last two decades in the generation of micrometer- and nanometer-scale materials. One of the major developments lies in the incorporation of multiple microfluidic devices onto single chips enabling emulsion generation at clinical and industrial-relevant scale. However\, most demonstrated successes have focused on producing simple emulsions; production upscaling of complex emulsion and materials have not been realized. In this thesis\, I will demonstrate new approaches and some early successes to fill this gap between lab-scale and industrially relevant scale production of complex emulsion and drop-based on-chip material synthesis. First\, a silicon-and-glass based microchip is developed for ultrahigh throughput on-chip photopolymerization of microgels. We demonstrate that the mechanical properties of microgels can be modulated by tuning the UV dosage and a massive parallelization of 4080 microfluidic synthesis lines on a 4-inch wafer. Second\, a new wettability patterning strategy\, along with the fabrication process\, is developed to pattern the hydrophobicity of a silicon-based microfluidic chip. We demonstrate wettability patterning with micrometer resolution and generation of both W/O/W and O/W/O double emulsions. Further\, the scalability of this approach is demonstrated with chips that incorporate 50 parallelized double-emulsion generating devices\, producing double emulsions in a high throughput manner (26.5 kHz double emulsions). Lastly\, we extend the above approach and develop a novel approach to perform surface wettability patterning via polymer enrichment and replica molding (SUPER)\, controlling the wettability of microfluidic channels made of a solvent-resistant PFPE-PEG copolymer network. We demonstrate the utility of this approach by fabricating a PFPE-PEG based microfluidic chip\, with hydrophobic/hydrophilic patterned microchannels\, to generate double emulsions.
URL:https://seasevents.nmsdev7.com/event/dissertation-defense-jingyu-wu/
LOCATION:Raisler Lounge (Room 225)\, Towne Building\, 220 South 33rd Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Dissertation or Thesis Defense
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