BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Penn Engineering Events - ECPv6.15.18//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Penn Engineering Events
X-ORIGINAL-URL:https://seasevents.nmsdev7.com
X-WR-CALDESC:Events for Penn Engineering Events
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/New_York
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20210314T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20211107T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20220313T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20221106T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20230312T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20231105T060000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20220119T153000
DTEND;TZID=America/New_York:20220119T163000
DTSTAMP:20260406T073020
CREATED:20220107T215630Z
LAST-MODIFIED:20220107T215630Z
UID:5953-1642606200-1642609800@seasevents.nmsdev7.com
SUMMARY:CBE Seminar: "Tackling Disease-Associated Biomolecules: From RNA Therapeutics to Single-Molecule Detection"
DESCRIPTION:Abstract\nThe functionality versatility of polymeric and nucleic acid materials provides diverse engineering opportunities for the detection and therapeutic targeting of disease-associated biomolecules. My work has encompassed nanoscale and microscale technologies to address challenges in cancer therapeutics and diagnostics\, from targeting the expression of dysregulated genes to probing rare protein biomarkers. I will first describe the design of a highly potent small interfering RNA nanoparticle delivery system that leverages approaches in nucleic acid engineering and polymer chemistry. Towards overcoming analytical barriers in clinical diagnostics\, I will then describe the development of ultrasensitive single-molecule detection technologies to measure low abundance proteins. By utilizing powerful molecular amplification methods and simple signal readouts\, these digital enzyme-linked immunosorbent assay (ELISA) platforms enable the detection of low attomolar (10-18 M) protein concentrations\, with over four orders-of-magnitude improvements in sensitivity over conventional protein detection methods. Importantly\, these methods democratize ultrasensitive protein detection\, enabling high-throughput\, high-multiplex digital measurements to be carried out with common laboratory instrumentation. \nFinally\, I will highlight the application of digital ELISA technology towards the development of an ultrasensitive blood test for a retrotransposon-encoded protein as a highly specific multi-cancer biomarker. Overall\, the development of these technologies can pave the way towards the future integration of materials and biomolecular engineering approaches with ultrasensitive bioanalytical tools for accelerating biomarker signature discovery and precision medicine.
URL:https://seasevents.nmsdev7.com/event/cbe-seminar-tackling-disease-associated-biomolecules-from-rna-therapeutics-to-single-molecule-detection/
LOCATION:Wu and Chen Auditorium (Room 101)\, Levine Hall\, 3330 Walnut Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Seminar
ORGANIZER;CN="Chemical and Biomolecular Engineering":MAILTO:cbemail@seas.upenn.edu
END:VEVENT
END:VCALENDAR