BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Penn Engineering Events - ECPv6.15.18//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Penn Engineering Events
X-ORIGINAL-URL:https://seasevents.nmsdev7.com
X-WR-CALDESC:Events for Penn Engineering Events
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/New_York
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20210314T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20211107T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20220313T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20221106T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20230312T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20231105T060000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20220209T153000
DTEND;TZID=America/New_York:20220209T163000
DTSTAMP:20260406T073346
CREATED:20220112T001652Z
LAST-MODIFIED:20220112T001652Z
UID:5988-1644420600-1644424200@seasevents.nmsdev7.com
SUMMARY:CBE Seminar: “Investigating Biomedical Challenges Through State-of-the-Art DNA-based Technology”
DESCRIPTION:Abstract \nDNA can serve purposes beyond conveying hereditary information – its highly specific Watson-Crick base pairing can also be used to direct the assembly of cells\, nanoparticles\, and proteins. Recently developed in the Sohn lab [1]\, high-throughput DNA-directed patterning takes advantage of the versatile and iterative aspects of photolithography to define clearly regions on an aldehyde-functionalized slide to which amine-terminated 20 nucleotide oligonucleotides are conjugated. By tagging antibodies\, liposomes\, or cells with the complementary oligonucleotide\, I can create patterns with high spatial resolution. In this talk\, I will demonstrate the versatility of high-throughput DNA-directed patterning through disparate applications\, including the immobilization of antibodies [2]\, the validation of a liposome model of SARS-CoV-2 [3]\, and an in vitro model of the tumor microenvironment. The advantages afforded by this technique enable me to validate ACE2-binding and antibody neutralization of different variant model liposomes and to study interactions of the multiple types of cells found in the bone marrow. By controlling the organization of cells with single-cell resolution and the ability to configure heterogeneous cellular environments\, DNA-directed patterning presents opportunities in the study of high complexity biomedical challenges.
URL:https://seasevents.nmsdev7.com/event/cbe-seminar-investigating-biomedical-challenges-through-state-of-the-art-dna-based-technology/
LOCATION:Wu and Chen Auditorium (Room 101)\, Levine Hall\, 3330 Walnut Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Seminar
ORGANIZER;CN="Chemical and Biomolecular Engineering":MAILTO:cbemail@seas.upenn.edu
END:VEVENT
END:VCALENDAR