BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Penn Engineering Events - ECPv6.15.19//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Penn Engineering Events
X-ORIGINAL-URL:https://seasevents.nmsdev7.com
X-WR-CALDESC:Events for Penn Engineering Events
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/New_York
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20180311T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20181104T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20190310T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20191103T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20200308T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20201101T060000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190918T150000
DTEND;TZID=America/New_York:20190918T160000
DTSTAMP:20260408T132519
CREATED:20190806T153639Z
LAST-MODIFIED:20190806T153639Z
UID:1787-1568818800-1568822400@seasevents.nmsdev7.com
SUMMARY:CBE Seminar: "Evolution of the Conformational-free Energy Landscapes of Proteins"
DESCRIPTION:Abstract: \nOne of the holy grails of drug-design is to obtain high-selectivity binding of a drug to the target protein\, an extremely challenging endeavor for proteins that share high sequence and structural similarity. We investigate several systems of high biological importance to elucidate how selectivity emerged during evolution and how it can inform the design of selective drugs. In particular\, we investigate three protein families\, i.e. human protein kinases\, receptors for plant hormone\, and strigolactone and SWEET transporters. These proteins show several orders of magnitude difference in their ligand affinity\, but share high sequence and structural similarity. This task involves understanding the structure-function relationship of proteins during evolution using advanced computational methods. We show how evolution-based methods such as the combination of reinforcement learning-based adaptive sampling and evolutionary couplings developed in our group could help simulate rare conformational change processes in proteins. In this talk\, we will not only demonstrate the utility of these new techniques to address a key challenge of understanding evolution of ligand perception\, but also the need\, feasibility and impact of computational evolutionary biophysics in understanding the fundamental questions in biology.
URL:https://seasevents.nmsdev7.com/event/cbe-seminar-evolution-of-the-conformational-free-energy-landscapes-of-proteins/
LOCATION:Wu and Chen Auditorium (Room 101)\, Levine Hall\, 3330 Walnut Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Seminar
ORGANIZER;CN="Chemical and Biomolecular Engineering":MAILTO:cbemail@seas.upenn.edu
END:VEVENT
END:VCALENDAR