BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Penn Engineering Events - ECPv6.15.19//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Penn Engineering Events
X-ORIGINAL-URL:https://seasevents.nmsdev7.com
X-WR-CALDESC:Events for Penn Engineering Events
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/New_York
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20180311T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20181104T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20190310T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20191103T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20200308T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20201101T060000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190911T150000
DTEND;TZID=America/New_York:20190911T160000
DTSTAMP:20260408T132518
CREATED:20190729T181355Z
LAST-MODIFIED:20190729T181355Z
UID:1732-1568214000-1568217600@seasevents.nmsdev7.com
SUMMARY:CBE Seminar: "Complexity in the Chemistry and Physics of Lipid Membranes as a Handle to Activate the Delivery of Cargo to Cells”
DESCRIPTION:Abstract: \nLipid materials having nanostructures that deviate from the conventional flat bilayer arrangement such as hexagonally packed lipid tubes and bi-continuous cubic phases are ubiquitous in nature. Their role remains elusive but over the years several pathologies and organelle functions have been coupled to lipid membrane structural complexity. In this talk\, we will discuss lipid membrane polymorphism and how it can be exploited to generate a new class of materials for the delivery of cargo to cells. We combine a number of techniques including X-ray scattering\, cryo-EM\, and cell culture to demonstrate that the structure of lipid nanoparticles is a powerful handle to boost the delivery of genes to cells. The simple argument that non-lamellar phases having intertwined nanoscale channels exist to increase surface-to-volume ratio might be insufficient to completely describe the experimental findings. \nIf there is time\, we will also introduce the concept of soft-material alloys. Lipids and polymers can mix in hybrid membranes having synergistic dynamical and structural properties; many of which are seen in lipid-protein membrane systems in nature
URL:https://seasevents.nmsdev7.com/event/cbe-seminar-complexity-in-the-chemistry-and-physics-of-lipid-membranes-as-a-handle-to-activate-the-delivery-of-cargo-to-cells/
LOCATION:Wu and Chen Auditorium (Room 101)\, Levine Hall\, 3330 Walnut Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Seminar
ORGANIZER;CN="Chemical and Biomolecular Engineering":MAILTO:cbemail@seas.upenn.edu
END:VEVENT
END:VCALENDAR