This hybrid seminar is co-hosted by the Departments of Bioengineering and Biology. Check email for the zoom link or contact ksas@seas.upenn.edu.

The study of biology at the single-cell level has relied on the development of precision measurement tools. Our research is focused on developing new technology for multimodal, precision measurement of single cells to move beyond cataloging cell types and push towards gaining a mechanistic understanding of the relationship between the molecules that define and maintain cell state. We build both hardware and software tools for measuring epigenetic regulation, gene expression, protein composition, and morphological phenotype at the single-cell level. This talk will focus on recent work applying single-cell genomic analysis to study T cell development and adipocyte development in model systems. Additionally, I will present a new method for measuring protein-DNA interactions and DNA methylation with long-read sequencing.