BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Penn Engineering Events - ECPv6.15.18//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Penn Engineering Events
X-ORIGINAL-URL:https://seasevents.nmsdev7.com
X-WR-CALDESC:Events for Penn Engineering Events
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/New_York
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20220313T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20221106T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20230312T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20231105T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20240310T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20241103T060000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230504T153000
DTEND;TZID=America/New_York:20230504T163000
DTSTAMP:20260404T103101
CREATED:20221220T152757Z
LAST-MODIFIED:20221220T152757Z
UID:8037-1683214200-1683217800@seasevents.nmsdev7.com
SUMMARY:BE Seminar: "Bioengineered Platforms for Mechanistic Understandings and Therapeutic Interventions" (Shyni Varghese\, Duke University)
DESCRIPTION:This talk will be held in person in Glandt Forum; snacks will be served. \nRegenerative medicine is an interdisciplinary field that has significant promise for treating compromised tissues and organs. In our laboratory\, we use a number of tools including biomaterials\, organoids\, quantitative modeling\, and animal models to gain new fundamental understandings and identify therapeutic targets. In this talk\, I will show several examples from our lab illustrating the use of such platforms to address key problems in tissue repair with aging and disease progression. First\, I will discuss our efforts in creating synthetic analogs of the extracellular matrix to direct stem cell commitment in vitro and in vivo with a focus on bone tissue repair and employing such platforms to understand molecular mechanisms underlying bone homeostasis and identifying new therapeutic targets (Shih et al.\, PNAS 111: 990\, 2014; 114: 5419 2017; Kang H et al.\, Biomacromolecules 16: 1050\, 2015; Shih et al.\, Sci. Adv. 5: eaax1387\, 2019). Next\, I will discuss how these understandings can be leveraged to develop therapeutic interventions to promote tissue repair and mitigate pain (Zeng et al.\, Adv. Mater. 32\, 2020). Finally\, I will end the talk by discussing our ongoing efforts in studying the effect of aging on neuroinflammation.
URL:https://seasevents.nmsdev7.com/event/be-seminar-shyni-varghese-duke-university/
LOCATION:Glandt Forum\, Singh Center for Nanotechnology\, 3205 Walnut Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Seminar
ORGANIZER;CN="Bioengineering":MAILTO:be@seas.upenn.edu
END:VEVENT
END:VCALENDAR