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DTSTART;TZID=America/New_York:20240208T153000
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SUMMARY:BE Seminar: "Mapping and engineering gene expression with chemical and spatial lenses" (Hailing Shi\, Broad Institute & MIT)
DESCRIPTION:Precise RNA expression\, tailored to specific brain regions\, cell types\, and subcellular compartments\, is pivotal for orchestrating complex brain functions. In the first part of my talk\, I will introduce a confocal imaging-based spatial transcriptomics platform\, STARmap\, that seamlessly combines in situ hybridization\, hydrogel tissue chemistry\, and in situ sequencing technologies. Leveraging scalable experimental and computational pipelines\, we have constructed a comprehensive spatial cell atlas of the mouse brain\, revealing subregion-specific cell types\, previously undiscovered tissue architectures\, and viral tropisms. The second part of my talk transits to chemical modifications on messenger RNAs (mRNAs) and their far-reaching implications in gene expression regulation and the development of RNA therapeutics. I will discuss the messenger-oligonucleotide conjugate RNAs (mocRNAs) design\, showcasing how we can harness chemical modifications for engineering enhanced gene delivery vectors. Looking into the future\, I aim to innovate and integrate chemical and spatial profiling approaches to understand tissue health and disease in-depth.
URL:https://seasevents.nmsdev7.com/event/be-seminar-mapping-and-engineering-gene-expression-with-chemical-and-spatial-lenses-hailing-shi-broad-institute-mit/
LOCATION:Raisler Lounge (Room 225)\, Towne Building\, 220 South 33rd Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Seminar
ORGANIZER;CN="Bioengineering":MAILTO:be@seas.upenn.edu
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