“Tissue Architecture Driven by Immune Cells”

John has developed multiplexed spatial omics techniques and computational tools to decode critical interactions within the multidimensional data (e.g., multiscale models and deep learning algorithms). He applied these tools to understand spatial relationships of cells within the healthy human intestine, inflammation induced cancers (esophageal cancer), and in T cell therapy for cancer. His lab will bridge spatial-omics technology, computational algorithm development, and engineering biology, to resolve spatiotemporal mechanisms governing multiple scales of biology, with a first application in cell therapies. His interdisciplinary training enables him to “speak” multiple scientific languages to facilitate critical collaborations across scientific disciplines.