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DTSTART;TZID=America/New_York:20211028T153000
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SUMMARY:BE Seminar: "Systems-level Analyses of the Human Gut Microbiome" (Ilana Lauren Brito)
DESCRIPTION:This seminar will be held live and broadcast on zoom – check your email for the link or contact ksas@seas.upenn.edu. \nA major question regarding the human gut microbiota is: by what mechanisms do our most intimately associated organisms affect human health? In this talk\, I will present several systems-level approaches that we have developed to address this fundamental question. My lab has pioneered methods that leverage protein-protein interactions to implicate bacterial proteins in human pathways linked to disease\, revealing for the first time a network of interactions that affect diseases such as colorectal cancer\, inflammatory bowel disease\, type 2 diabetes and obesity that can be mined for novel therapeutics and therapeutic targets. I will present novel methods that that enable deeper insight into the transcriptome of organisms within our guts and their spatial localization. Finally\, I will shift to the problem of the spread of antibiotic resistance\, in which the gut microbiota are implicated. Pathogens become multi-drug resistance by acquiring resistance traits carried by the gut microbiota. Studying this process in microbiomes is inherently difficult using current methods. I will present several methods that enable tracking of genes within the microbiome and computational tools that predict the network of gene transfer between bacteria. Overall\, these systems-level tools provide deep insight into the knobs we can turn to engineer outcomes within the microbiome that can improve human health.
URL:https://seasevents.nmsdev7.com/event/be-seminar-ilana-lauren-brito/
LOCATION:Moore 216\, 200 S. 33rd Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Seminar
ORGANIZER;CN="Bioengineering":MAILTO:be@seas.upenn.edu
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