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DTSTART;TZID=America/New_York:20210211T150000
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CREATED:20210112T135214Z
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UID:3828-1613055600-1613059200@seasevents.nmsdev7.com
SUMMARY:BE Seminar: "Multi-input Chemical Control With Computationally Designed Proteins for Research Tools and Cell Therapies" (Glenna Wink Foight)
DESCRIPTION:This event will be held virtually via Zoom – check email for details or contact ksas@seas.upenn.edu \nProtein modules that are responsive to small molecule inputs have enabled control of cellular processes for decades’ worth of important mechanistic studies. More recently\, they have gained attention as a means of control for improved safety of cellular therapies. To date\, most small molecule-responsive systems have been adapted from natural proteins\, which provide limited control behaviors and often rely on small molecules with non-ideal properties for use in humans. I will describe how we have used computational protein design to move beyond these naturally occurring systems to create a new set of molecular tools that are responsive to multiple clinically approved drugs. The unique architecture of our system enables more complex control behaviors for multiple cellular outputs. I will describe applications of this designed system in the control of mammalian cytoskeletal signaling\, transcription\, and CAR T-cell therapy. \n 
URL:https://seasevents.nmsdev7.com/event/be-seminar-glenna-wink-foight/
CATEGORIES:Seminar
ORGANIZER;CN="Bioengineering":MAILTO:be@seas.upenn.edu
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