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SUMMARY:BE Seminar: "Imaging the Brain for Deeper\, Finer\, and More Diverse Insight" (Fei Xia\, Ecole Normale Supérieure)
DESCRIPTION:The brain is a powerful organ that regulates health and drives intelligence. How can we see more clearly into the working brain to understand it better? High-resolution optical microscopy has long been an ideal tool due to its spatial sub-micron precision and specificity. However\, achieving the necessary spatio-temporal scale for further advancing our understanding of the brain remains a challenge. The primary obstacle originates from the inhomogeneous nature of tissues\, which distort light and compromise imaging depth\, precision\, and information. \nIn this talk\, I will introduce new in vivo deep tissue optical microscopy platforms advanced in microscope design and computational tools\, to address existing challenges. By moving towards longer wavelengths for one-\, two-\, and three-photon microscopy\, we have achieved simultaneous deep structural and functional imaging through an entire cortical column with multiple label-free and fluorescence contrasts. With precise control of light\, we have enabled adaptive optical imaging of dendritic spines and myelinated axons up to the hippocampus. With a new AI-enabled tool\, we have sped up volumetric 3D imaging for microvasculature\, neurons\, and dendrites. These techniques advance toward imaging the dynamic\, cell-type-specific processes and microvasculature within the living brain. I will conclude by discussing the opportunities these enabling optical microscopy techniques offer for biology and clinical applications.
URL:https://seasevents.nmsdev7.com/event/be-seminar-fei-xia-ecole-normale-superieure/
LOCATION:Raisler Lounge (Room 225)\, Towne Building\, 220 South 33rd Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Seminar
ORGANIZER;CN="Bioengineering":MAILTO:be@seas.upenn.edu
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