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SUMMARY:BE Seminar: "Developments in Stem Cell-Derived Islets for Diabetes Cell Replacement Theory" (Jeffrey R. Millman\, Washington University School of Medicine)
DESCRIPTION:This is a hybrid seminar which will be held in Glandt Forum (Singh Center) and via Zoom (link coming soon). \n“Developments in Stem Cell-Derived Islets for Diabetes Cell Replacement Theory” \nCellular and tissue engineering promises new therapeutic options for people suffering from a wide range of diseases. Differentiation of stem cells is a powerful renewable source of these functional replacement cells and tissues that can be grown in the laboratory. Diabetes is cause by the death or dysfunction of insulin-secreting islets\, which are a tissue type found in the pancreas that contain β cells and other endocrine cell types. We have recently developed approaches combining modulating the actin cytoskeleton and signal transduction pathways during differentiation to produce stem cell-derived islets (SC-islets) capable of undergoing glucose-stimulated insulin secretion\, their primary function. We have further expanded this approach to make SC-islets from patients with diabetes and used CRISPR-Cas9 to correct their diabetes-causing mutations. Upon transplantation into mice with severe pre-existing diabetes\, these SC-islets rapidly restore normoglycemia and can maintain this functional cure for a year. Our hope is that one day this technology can be used to replace unhealthy islets in patients for therapy and provide a better disease-in-a-dish model to discover new drugs to prevent\, stop\, or reverse diabetes progression.
URL:https://seasevents.nmsdev7.com/event/be-seminar-developments-in-stem-cell-derived-islets-for-diabetes-cell-replacement-theory-jeffrey-r-millman-washington-university-school-of-medicine/
LOCATION:Glandt Forum\, Singh Center for Nanotechnology\, 3205 Walnut Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Seminar
ORGANIZER;CN="Bioengineering":MAILTO:be@seas.upenn.edu
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