In my talk, I will first describe one of the main projects in my lab that investigates the underlying cellular-molecular mechanisms for changes in alcohol sensitivity of crayfish with different prior social experiences. In this context, I will explain why “simple” invertebrates may provide unique advantages for studying complex phenomena such as socially-dependent drug effects. Crayfish are inexpensive and easily maintained in the laboratory, and they have an accessible nervous system with large, identified neurons that link directly to behavior and can sustain many hours of experimental study. This allows for high precision and reproducibility and makes crayfish a suitable model not just for investigating neurobehavioral questions, but for developing and improving biomedical devices and tools. In the second part of my talk, I will illustrate two projects that are currently ongoing in collaboration with engineering colleagues at UMD. The first one aims to develop nanoparticles that wirelessly activate and record neural activity patterns using microwave signals. Preliminary data using individual neurons of the ex vivo crayfish nerve cord revealed that single action potentials can be robustly recorded by activating microwave signals in a nanoscale magnetic tunnel junction. The future goal of this project is to develop this technique for non-invasive monitoring and modulating of activity in brains of higher complexity. The second project interfaces the crayfish ex vivo ventral nerve cord and innervated hindgut with a multi-sensor 3D printed platform that contains cultured human gut cells and interchangeable colonies of microbiota. The physiological responses to serotonin release from cell cultures will be measured and quantified in crayfish neurons of the central and enteric nervous system and on corresponding hindgut motility with intracellular electrophysiology and motion tracking. The long-term goal is to develop a real-time, high-throughput discovery platform that allows detailed investigation of the cellular processes underlying the gut-brain axis.