BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Penn Engineering Events - ECPv6.16.3//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Penn Engineering Events
X-ORIGINAL-URL:https://seasevents.nmsdev7.com
X-WR-CALDESC:Events for Penn Engineering Events
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/New_York
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20230312T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20231105T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20240310T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20241103T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20250309T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20251102T060000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241010T153000
DTEND;TZID=America/New_York:20241010T163000
DTSTAMP:20260603T050110
CREATED:20240627T183240Z
LAST-MODIFIED:20240627T183240Z
UID:11656-1728574200-1728577800@seasevents.nmsdev7.com
SUMMARY:BE Seminar: "Synthetic reconstitution of complex cellular behavior" (Ahmad Khalil\, Boston University)
DESCRIPTION:Cells use genetically-encoded molecular circuits to execute diverse biological functions. We are developing novel tools of synthetic biology that allow us to construct regulatory circuitry inside living cells that recapitulate complex functions like those seen in nature. In this talk\, I will describe how we use this approach to achieve three objectives. First\, I will demonstrate how synthetic reconstitution provides a powerful way to understand fundamental principles of regulatory networks\, which we have applied to guide discoveries in eukaryotic transcription regulation and epigenetics. Second\, I will describe our advancements in developing synthetic circuit technologies that enable precise\, instructive control of therapeutic human cell function to address challenges in emerging cellular therapies\, such as CAR-T cells for cancer. Finally\, I will share a future vision of how synthetic reconstitution can be used to engineer cells with little or no intrinsic therapeutic potential into powerful and scalable engines for generating custom\, therapeutically-relevant molecules. Overall\, by learning how to build biological systems from scratch\, our broad goal is to connect the basic molecular building blocks of life to complex cellular behavior and ultimately to clinical applications.
URL:https://seasevents.nmsdev7.com/event/be-seminar-ahmad-khalil-boston-university/
LOCATION:216 Moore Building
CATEGORIES:Seminar
ORGANIZER;CN="Bioengineering":MAILTO:be@seas.upenn.edu
END:VEVENT
END:VCALENDAR