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CREATED:20240108T172513Z
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SUMMARY:BE Seminar: "Synthetic and Chemical Biology Routes to Unveiling Host-Pathogen Dialogue" (Aerin Yang\, Stanford)
DESCRIPTION:Disease processes within the human body are shaped by the dynamic interplay between\ninvading pathogens and the host’s defense mechanisms. The intricate molecular\ninteraction involves continuous modifications of both host and pathogen proteins\, driven\nby posttranslational modifications (PTMs) and coevolutionary mutations\, to finely regulate\ntheir interactions with binding partners. In this talk\, I will elucidate my research efforts\naimed at unraveling these complex molecular interactions through the integration of\nchemical and synthetic biology approaches. Firstly\, I will delve into my work about\nchemical biology pathways for site-specific protein modification\, advancing our\nunderstanding of PTM biology. Next\, I will describe the recently invented “library-on-\nlibrary” approaches designed to co-evolve protein-protein interactions (PPIs). This\ntechnique addresses a pivotal challenge in understanding crucial PPIs in immunology\,\nincluding those within host-pathogen interfaces.
URL:https://seasevents.nmsdev7.com/event/be-seminar-aerin-yang-stanford/
LOCATION:Raisler Lounge (Room 225)\, Towne Building\, 220 South 33rd Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Seminar
ORGANIZER;CN="Bioengineering":MAILTO:be@seas.upenn.edu
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