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DTSTART;TZID=America/New_York:20230919T100000
DTEND;TZID=America/New_York:20230919T113000
DTSTAMP:20260404T050048
CREATED:20230831T212927Z
LAST-MODIFIED:20230831T212927Z
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SUMMARY:MEAM Seminar: "Insect Respiratory Biomechanics and Insect-inspired Microfluidics"
DESCRIPTION:Insect respiration is characterized by the rapid transport of respiratory gases within the organism and efficient exchange with the external environment. This unique system is comprised of a network of tracheal tubes that directly supply oxygen to the cells throughout the body\, eliminating the need for blood as an intermediate oxygen carrier. The remarkable diversity of insects and their astonishing metabolic rates\, the highest in the animal kingdom for flying insects\, provide evidence of the success of their respiratory strategy. Microfluidic technology\, particularly in the domains of gas microfluidics and tissue engineering\, stands to benefit from emulating the mechanical proficiency demonstrated by insects in manipulating fluids at the microscale. Despite this significance\, our understanding of the fundamental principles underlying insect respiration remains incomplete. In this talk\, we will present mathematical\, microfluidic\, and computational modeling of insect respiration based on data from large\, inactive and small\, highly active insects\, including the darkling beetle Zophobas morio and the fruit fly Drosophila melanogaster. Our results suggest that insect respiration is highly versatile with largely automated\, distributed control mechanisms. Finally\, we will present our work developing microfluidic infusion pumps based on principles of insect respiration. They are powered by the arterial pulse and have the potential to drastically reduce the profile of ambulatory infusion pumps for the delivery of insulin\, chemotherapy\, other therapeutics\, and vaccines.
URL:https://seasevents.nmsdev7.com/event/meam-seminar-insect-respiratory-biomechanics-and-insect-inspired-microfluidics/
LOCATION:Wu and Chen Auditorium (Room 101)\, Levine Hall\, 3330 Walnut Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Seminar
ORGANIZER;CN="Mechanical Engineering and Applied Mechanics":MAILTO:meam@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230920T090000
DTEND;TZID=America/New_York:20230920T100000
DTSTAMP:20260404T050048
CREATED:20230907T152741Z
LAST-MODIFIED:20230907T152741Z
UID:10007674-1695200400-1695204000@seasevents.nmsdev7.com
SUMMARY:MEAM Ph.D. Thesis Defense: "Multi-Scale Probing of Colloidal Sedimentation Dynamics in Active Suspensions"
DESCRIPTION:Microorganisms\, although challenging to observe\, are ubiquitous in both natural ecosystems and industries. They inhabit diverse environments: natural ones ranging from small river tributaries and lakes to oceans\, as well as in industrial settings\, like wastewater treatment plants and food manufacturing. In these diverse contexts\, microorganisms coexist with settling particles\, a process heavily influenced by gravity. Consequently\, gravity significantly influences microorganisms’ behaviors\, impacting aspects such as locomotion and nutrient uptake. The presence of microorganisms alongside colloidal particles\, specifically\, can influence industrial processes and transport properties. The comprehension of microorganisms’ physical and biological behaviors in aquatic environments\, especially under external forces like gravity\, remains elusive and challenging. \nIn this thesis\, I explore the dynamics of spherical colloidal sedimentation in the presence of swimming Escherichia coli across various concentrations within the dilute regime. The sedimentation processes receive comprehensive characterization across length scales\, through the examination of macro-scale settling speeds\, meso-scale concentration profiles\, and micro-scale particle diffusivities. First\, I showcase how bacterial activity affects the concentration profiles of spherical particles—an alteration describable through an advection-diffusion equation with an added population dynamics term. Subsequently\, I characterize the sedimentation speed of spherical particles across different bacterial concentrations\, unveiling the emergence of two sedimentation fronts: particle- and bacteria-rich fronts. Even passive systems of poly-dispersed (by size) particles are known to show segregating sedimentation fronts; larger (and faster) settling particles will separate from smaller (and slower) ones\, given enough time. In this context\, heightened activity influences sedimentation speeds and the associated timescales tied to the appearance of the bacteria front. These timescales pertaining to the second front yield a phenomenological model that captures the sedimentation of passive particles within active fluids. Lastly\, I explored the interactions between particles and bacteria in the presence of gravity\, uncovering that bacterial-induced convective motions reduce the convective transport of colloidal particles. By increasing bacterial concentration\, particle convection diminishes and nearly stabilizes. These observations reveal a correlation with measurements of macro-scale settling speeds. I demonstrate that the emergence of this phenomenon is associated with the development of complex bioconvection patterns. Overall\, this dissertation illuminates the intricate interplay between microorganisms and particles in the presence of gravity\, revealing nontrivial effects.
URL:https://seasevents.nmsdev7.com/event/meam-ph-d-thesis-defense-multi-scale-probing-of-colloidal-sedimentation-dynamics-in-active-suspensions/
LOCATION:Raisler Lounge (Room 225)\, Towne Building\, 220 South 33rd Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Doctoral,Dissertation or Thesis Defense
ORGANIZER;CN="Mechanical Engineering and Applied Mechanics":MAILTO:meam@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230920T120000
DTEND;TZID=America/New_York:20230920T131500
DTSTAMP:20260404T050048
CREATED:20230911T150135Z
LAST-MODIFIED:20230911T150135Z
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SUMMARY:ASSET Seminar: "The Road to Explainable AI v2.0" (Eric Wong\, Penn)
DESCRIPTION:ABSTRACT:\n“A.I. has an explainability crisis”—Fortune Magazine. If you ask an ML researcher about explainability\, you’ll find that there are a large number of interpretability methods with no clear consensus on what to use. In fact\, it isn’t clear what many of these explanations even mean\, let alone how they can be used. I will discuss a potential vision that moves beyond these limitations to the next generation of explainable AI: interpretations with provable guarantees and well-defined takeaways. \nBIO:  \nEric Wong is an Assistant Professor in the Department of Computer and Information Science at the University of Pennsylvania. He researches the foundations of robust systems\, building on elements of machine learning and optimization to debug\, understand\, and develop reliable systems.
URL:https://seasevents.nmsdev7.com/event/asset-seminar-aditi-raghunathan-carnegie-mellon-university/
LOCATION:Levine 307\, 3330 Walnut Street\, Philadelphia\, PA\, 19104\, United States
ORGANIZER;CN="AI-enabled Systems%3A Safe%2C Explainable%2C and Trustworthy (ASSET) Center":MAILTO:asset-info@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230920T120000
DTEND;TZID=America/New_York:20230920T133000
DTSTAMP:20260404T050048
CREATED:20230915T180947Z
LAST-MODIFIED:20230915T180947Z
UID:10007695-1695211200-1695216600@seasevents.nmsdev7.com
SUMMARY:CBE Doctoral Dissertation Defense: "Molecular Mechanisms of Spatiotemporal Gene Control in Early Embryonic Development"
DESCRIPTION:Development of a newly fertilized embryo is a dynamic\, complex\, and highly coordinated process that requires precise genetic regulation and control. As the embryo develops\, DNA regulatory elements known as enhancers drive gene expression patterns in specific regions of an organism at a particular time. Mis-regulation of gene expression due to mutations in enhancers can result in severe disease phenotypes and developmental defects. However\, understanding the fundamental mechanisms that activate and regulate precise transcription remains challenging. This thesis aims to elucidate the molecular mechanisms of enhancer-mediated transcriptional regulation in high spatiotemporal resolution in different genetic contexts. \nEarly development is largely controlled by maternally deposited proteins\, while the zygotic genome remains transcriptionally silent. The transition from maternal to zygotic control has been extensively studied\, yet we still lack a comprehensive understanding of the processes that result in zygotic genome activation. In Chapter 2\, we identify distinct yet overlapping mechanisms of nuclear to cytoplasmic (N/C) ratio control on transcription driven by various enhancers under different genetic perturbations. \nEnhancers contain unique binding sites for various proteins\, known as transcription factors (TFs)\, that regulate spatiotemporal expression of a target gene. Many enhancers contain multiple binding sites for the same TF and the specific contribution of the various TF binding sites to the overall expression of a target gene is unclear. In Chapter 3\, we characterize enhancer-mediated gene expression upon systematic modulation of TF binding sites. We find that mutating a single TF binding site results in a dramatic reduction in mRNA production. Through thermodynamic modeling\, we uncover the synergistic capabilities of each binding site to the total transcriptional dynamics. \nIn this thesis we use a combination of live imaging\, CRISPR/Cas9 genome editing technology\, quantitative analysis\, and mathematical modeling to explore a new world of gene regulation and transcriptional dynamics. By understanding the fundamental mechanisms that spatiotemporally control and modulate the expression of essential developmental genes\, we can gain insights into gene mis-regulation and serious diseases.
URL:https://seasevents.nmsdev7.com/event/cbe-doctoral-dissertation-defense-molecular-mechanisms-of-spatiotemporal-gene-control-in-early-embryonic-development/
LOCATION:Towne 225
CATEGORIES:Dissertation or Thesis Defense
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230920T150000
DTEND;TZID=America/New_York:20230920T160000
DTSTAMP:20260404T050048
CREATED:20230913T152449Z
LAST-MODIFIED:20230913T152449Z
UID:10007692-1695222000-1695225600@seasevents.nmsdev7.com
SUMMARY:Fall 2023 GRASP SFI: David Lentink\, University of Groningen\, "Avian Inspired Design"
DESCRIPTION:This is a hybrid event with in-person attendance in Levine 307 and virtual attendance on Zoom. This week’s speaker will be virtual.  \nABSTRACT\nMy lab focusses on understanding every aspect of bird flight to improve flying robots—because birds fly further\, longer\, and more reliable in complex visual and wind environments. I use a multidisciplinary lens that integrates biomechanics\, sensorimotor control and organismal & evolutionary biology with aerospace engineering\, robotics and aerodynamics to advance our systems understanding of avian flight. The experimental approaches range from flying birds in custom-designed flight arenas\, scanning their 3D shape at high-speed and unraveling their musculoskeletal control strategies to making innovative direct aerodynamic force measurements in flight. I will show how these and other ongoing studies in my lab have inspired new biohybrid soft morphing aerial robots that we design and fly in my lab.
URL:https://seasevents.nmsdev7.com/event/fall-2023-grasp-sfi-david-lentink/
LOCATION:Levine 307\, 3330 Walnut Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Seminar
ORGANIZER;CN="General Robotics%2C Automation%2C Sensing and Perception (GRASP) Lab":MAILTO:grasplab@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230920T153000
DTEND;TZID=America/New_York:20230920T163000
DTSTAMP:20260404T050048
CREATED:20230905T201628Z
LAST-MODIFIED:20230905T201628Z
UID:10007669-1695223800-1695227400@seasevents.nmsdev7.com
SUMMARY:CBE Seminar: "Facile Synthesis of Polymeric Nanomaterials via Chemical Vapor Deposition Techniques" (Yang\, Cornell)
DESCRIPTION:Polymer is often considered one of the most prevalent materials in the modern age. While it has been predominantly synthesized in solution and processed into a variety of macroscopic sizes and shapes\, the need for programmability in materials’ microscopic properties has challenged the traditional synthesis approaches. Recent advances in vacuum-based synthesis technologies\, such as the initiated Chemical Vapor Deposition (iCVD) and Condensed Droplet Polymerization (CDP)\, have enabled a new mode of control over material properties during polymerization. Distinct from prior research that has placed a strong emphasis on the design of monomer molecular structure and controlled polymerization\, the all-dry synthesis enables manipulation of the molecular interactions\, such as molecular complexing and nanoscale dewetting\, to achieve programmable nanoscale structures. In this talk\, I will use two examples to illustrate the underlying principles and potential benefits of this distinct synthesis paradigm: (i) enabling vapor-phase molecular complexation during polymerization to achieve an unprecedented range of molecular weight\, mechanical properties\, and film morphology; (ii) leveraging nanoscale dewetting of nonpolar liquids to create polymeric nanodomes with spatiotemporal resolution on the nanoscale. Taken together\, these advances in manipulating the physicochemical interactions during polymerization are poised to open up a new dimension in the design and synthesis of programmable polymeric materials\, benefiting numerous existing and future technologies\, ranging from nano-optics to drug delivery.
URL:https://seasevents.nmsdev7.com/event/cbe-seminar-facile-synthesis-of-polymeric-nanomaterials-via-chemical-vapor-deposition-techniques-yang-cornell/
LOCATION:Wu and Chen Auditorium (Room 101)\, Levine Hall\, 3330 Walnut Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Seminar
ORGANIZER;CN="Chemical and Biomolecular Engineering":MAILTO:cbemail@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230921T103000
DTEND;TZID=America/New_York:20230921T120000
DTSTAMP:20260404T050048
CREATED:20230815T183247Z
LAST-MODIFIED:20230815T183247Z
UID:10007634-1695292200-1695297600@seasevents.nmsdev7.com
SUMMARY:MSE Seminar: "DumoLab Research: Regenerative Architecture with Biomaterials" Weitzman School of Design - University of Pennsylvania
DESCRIPTION:Dr. Mogas-Soldevila will give an overview on her DumoLab research at the Weitzman School of Design at Penn. Her works focuses on regenerative material practices bridging science\, engineering\, and the arts. DumoLab builds scholarship for materials design critique\, and translates biomedical materials used in implants\, drug delivery\, and tissue scaffolding\, into robust materials for use in product and architectural design that nurture both humans and the planet. Interdisciplinary research areas push forward biomaterials science for non-medical applications\, growth-like large-scale and ambient conditions manufacturing\, and new testing protocols and aesthetics for bio-composites in consumer products and the built environment.
URL:https://seasevents.nmsdev7.com/event/mse-seminar-dumolab-research-regenerative-architecture-with-biomaterials-weitzman-school-of-design-university-of-pennsylvania/
LOCATION:Wu and Chen Auditorium (Room 101)\, Levine Hall\, 3330 Walnut Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Seminar
ORGANIZER;CN="Materials Science and Engineering":MAILTO:johnruss@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230921T150000
DTEND;TZID=America/New_York:20230921T160000
DTSTAMP:20260404T050048
CREATED:20230911T184251Z
LAST-MODIFIED:20230911T184251Z
UID:10007687-1695308400-1695312000@seasevents.nmsdev7.com
SUMMARY:ESE PhD Thesis Defense: "Toward High-performance Simple Models of Legged Locomotion"
DESCRIPTION:This thesis addresses the challenges of model-based planning and control in legged locomotion\, particularly the trade-off between computational speed and robot performance presented by different levels of model complexities. Full-order models\, while rich in detail\, are often too computationally demanding for real time planning\, whereas conventional reduced-order models (ROMs) tend to oversimplify the dynamics\, limiting overall performance potential. Our research focuses on a novel approach — the direct optimization of ROMs. This study seeks to enhance the performance of legged robots by automatically discovering the optimal ROMs that simultaneously deliver high robot performance while maintaining the necessary low dimensionality for real time planning applications. In the beginning of the thesis\, we focus on a special case where we aim to find whole-body orientation coordinates (WBO) for legged robots that minimize angular momentum errors. This optimal WBO\, while being a simple forward kinematic function\, serves as a proxy of the real angular momentum and can be applied to complex tasks such as humanoid natural walking. In the second part of the thesis\, we formulate a bilevel optimization problem to find optimal ROMs agnostic to controller choices\, driven by user-defined objectives and task distributions. The results show substantial improvements in walking speed\, ground slope adaptability and torque efficiency on a bipedal robot Cassie. Lastly\, we cast the ROM optimization problem as a model-based reinforcement learning (RL) problem to further improve the model performance. This does not only show better performance improvements in experiment but also provides an easier way to implement model optimization and to realize the model performance on the robot.
URL:https://seasevents.nmsdev7.com/event/ese-phd-thesis-defense-toward-high-performance-simple-models-of-legged-locomotion/
LOCATION:Raisler Lounge (Room 225)\, Towne Building\, 220 South 33rd Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Dissertation or Thesis Defense
ORGANIZER;CN="Electrical and Systems Engineering":MAILTO:eseevents@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230921T150000
DTEND;TZID=America/New_York:20230921T170000
DTSTAMP:20260404T050048
CREATED:20230905T133811Z
LAST-MODIFIED:20230905T133811Z
UID:10007667-1695308400-1695315600@seasevents.nmsdev7.com
SUMMARY:BE Doctoral Dissertation Defense: "Pooled tagging of endogenous proteins for exploration of the human proteome driven by prime editing"
DESCRIPTION:The Department of Bioengineering at the University of Pennsylvania and Dr. Ophir Shalem are pleased to announce the Doctoral Dissertation Defense of Henry Sanchez.\n\n \n\nTitle: Pooled tagging of endogenous proteins for exploration of the human proteome driven by prime editing\nDate: September 21\, 2023\nTime: 3:00pm\nLocation: Colket Translational Research Building (Room 4040)\n\n\nThe public is welcome to attend.
URL:https://seasevents.nmsdev7.com/event/be-doctoral-dissertation-defense-pooled-tagging-of-endogenous-proteins-for-exploration-of-the-human-proteome-driven-by-prime-editing/
LOCATION:Colket Translational Research Building (Room 4040)
CATEGORIES:Doctoral,Graduate,Student,Dissertation or Thesis Defense
ORGANIZER;CN="Bioengineering":MAILTO:be@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230921T153000
DTEND;TZID=America/New_York:20230921T163000
DTSTAMP:20260404T050048
CREATED:20230726T134632Z
LAST-MODIFIED:20230726T134632Z
UID:10007612-1695310200-1695313800@seasevents.nmsdev7.com
SUMMARY:BE Seminar: "Engineering the cell-matrix interface – understanding and guiding cell function" (Claudia Loebel\, University of Michigan)
DESCRIPTION:The native extracellular microenvironment dynamically remodels as cells synthesize\, assemble\, and remodel their surroundings during tissue development\, injury\, and repair. In my research group\, we use engineered systems to both probe mechanisms of cell-extracellular matrix (ECM) interactions (e.g.\, mechanobiology) and to guide cell function towards therapeutic behaviors (e.g.\, tissue repair/regeneration). In this seminar\, I will share our recent efforts to visualize and identify the composition of secreted ECM to better understand cellular responses and to design programmable soft materials that harness dynamic cell-ECM interactions.\nWe have used these systems to reproduce folding morphologies of epithelial tissues (e.g.\, airway constriction)\, and to manipulate secreted ECM components as means to better understand the evolution of matrix in organ development (using lung organoids) and repair (using ex vivo lung tissue). Our evolving understanding of matrix dynamics and turnover will not only open up new avenues for understanding biological mechanisms but will also allow us to design better materials systems for therapeutic interventions.
URL:https://seasevents.nmsdev7.com/event/be-seminar-engineering-the-cell-matrix-interface-understanding-and-guiding-cell-function-claudia-loebel-university-of-michigan/
LOCATION:216 Moore Building
CATEGORIES:Seminar
ORGANIZER;CN="Bioengineering":MAILTO:be@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230922T100000
DTEND;TZID=America/New_York:20230922T110000
DTSTAMP:20260404T050048
CREATED:20230918T142731Z
LAST-MODIFIED:20230918T142731Z
UID:10007696-1695376800-1695380400@seasevents.nmsdev7.com
SUMMARY:PRECISE Seminar: Designing Computing Systems for Robotics and Physically Embodied Deployments
DESCRIPTION:
URL:https://seasevents.nmsdev7.com/event/precise-seminar-designing-computing-systems-for-robotics-and-physically-embodied-deployments/
LOCATION:Levine 307\, 3330 Walnut Street\, Philadelphia\, PA\, 19104\, United States
ORGANIZER;CN="PRECISE":MAILTO:wng@cis.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230922T110000
DTEND;TZID=America/New_York:20230922T120000
DTSTAMP:20260404T050048
CREATED:20230829T194706Z
LAST-MODIFIED:20230829T194706Z
UID:10007652-1695380400-1695384000@seasevents.nmsdev7.com
SUMMARY:ESE Fall Seminar - "Tools for designing some exciting chips"
DESCRIPTION:There is an enormous interest in developing customized\, domain-specific systems-on-a-chip.  Continued improvement in computing efficiency requires functional specialization of hardware designs. But designing complex chips is difficult.   This talk presents the Chipyard framework\, an integrated SoC design\, simulation\, and implementation environment for specialized compute systems. Chipyard includes configurable\, composable\, open-source\, generator-based IP blocks that can be used across multiple stages of the hardware development flow while maintaining design intent and integration consistency. We discuss some sample designs\, the use of the framework in classes\, and opportunities for extension and improvement.
URL:https://seasevents.nmsdev7.com/event/ese-fall-seminar-title-tbd-2/
LOCATION:Berger Auditorium (Room 13)\, Skirkanich Hall\, 210 South 33rd Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Colloquium
ORGANIZER;CN="Electrical and Systems Engineering":MAILTO:eseevents@seas.upenn.edu
END:VEVENT
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