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DTSTART;TZID=America/New_York:20230705T100000
DTEND;TZID=America/New_York:20230705T100000
DTSTAMP:20260404T083533
CREATED:20230629T151247Z
LAST-MODIFIED:20230629T151247Z
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SUMMARY:ESE PhD Thesis Defense: "Chemical vapor deposition synthesis of graphene and transition metal dichalcogenides and their applications"
DESCRIPTION:2D materials is a rapidly expanding class of materials that have captivated academia and industry with their ultrathin nature and remarkable properties. Graphene\, the first discovered material\, shows exceptional mechanical strength and superior electrical properties\, presenting exciting probabilities in many applications. Combined with its large surface area and biocompatibility\, graphene is particularly promising for the development of highly sensitive and selective biosensors. However\, the application of graphene is limited by its lack of a bandgap\, making it unusable for advanced logic circuits. 2D materials beyond graphene are thus being explored. Transition metal dichalcogenides (TMDs) are representative candidates possessing a variety of properties including tunable bandgaps. Conventionally\, both graphene and TMDs are produced by mechanical exfoliation\, but this method is low-yield and not suitable for large-scale applications such as biosensing. Therefore\, a reliable synthesis strategy for these materials is urgently needed. In this thesis\, synthesis of graphene and TMDs by chemical vapor deposition (CVD) is explored. The CVD synthesized graphene sheet has monolayer structure which can be inch scale in size\, enabling the scalable fabrication of graphene biosensors. We develop the fabrication process of graphene biosensors and explore their biosensing applications\, where the sensors are used to study the interaction between a specially designed water-soluble mu opioid receptor (wsMOR) and G-protein. The biosensors are able to record the in vitro interaction between the two molecules with high sensitivity. The CVD growth of TMDs is also investigated. Rapid growth of inch-scale monolayer MoSe2 continuous film has been synthesized on insulating substrates\, based on a spin-coating\, NaCl assisted CVD approach. This approach is promising to be extended to the growth of other semiconducting TMDs\, benefit to the batch production of large-area TMD electronics. Additionally\, we studied the CVD synthesis of TMDs with controlled layer numbers at controlled locations. Various approaches are used to demonstrate the high quality of the materials and field-effect transistor measurements indicate their potential in making advanced electronic devices.
URL:https://seasevents.nmsdev7.com/event/ese-phd-thesis-defense-chemical-vapor-deposition-synthesis-of-graphene-and-transition-metal-dichalcogenides-and-their-applications/
LOCATION:Room 337\, Towne Building\, 220 South 33rd Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Dissertation or Thesis Defense
ORGANIZER;CN="Electrical and Systems Engineering":MAILTO:eseevents@seas.upenn.edu
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230706T100000
DTEND;TZID=America/New_York:20230706T120000
DTSTAMP:20260404T083533
CREATED:20230622T130209Z
LAST-MODIFIED:20230622T130209Z
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SUMMARY:CBE PhD Thesis Defense: "Comparative analysis of aneuploidy in suspension cancer lines and solid tumors: insights from single cell sequencing approaches"
DESCRIPTION:Aneuploidy\, a cancer hallmark\, has intrigued researchers due to its near-universal presence in cancer. However\, studying its impact is challenging due to the involvement of numerous genes and the difficulty in creating suitable models. Advances in sequencing technology and the vast data available in the Cancer Genome Atlas (TCGA) enabled us to use the p53-null suspension cancer cell line\, THP-1\, as a model to explore genomic instability in hematopoietic cancer. We aimed to understand why non-adherent cancers typically exhibit lower aneuploidy levels compared to solid tumors. Through an examination of the spindle assembly checkpoint (SAC) and the application of physical and chemical perturbations\, we discovered that suspension cancer lines displayed no discernible differences in SAC functionality or sensitivity to external perturbations compared to solid tumors. Notably\, chemical perturbations led to the emergence of copy number variations (CNVs) that provided proliferative advantages to daughter cells. Introduction of p53 into THP-1 did not rescue aneuploidy levels\, aligning with previous research suggesting its upstream role in suppressing aneuploidy. However\, the introduction of p53 did restore downstream p21 pathways\, which are known to suppress cancer cell proliferation. Interestingly\, the expected growth suppression was found to be independent of p21 levels. Furthermore\, the engineered THP-1 exhibited reduced p53 levels after treatment with reversine and etoposide\, unlike adherent cancer cells. These findings indicate distinct p53 pathways in liquid cancer lines that ensure genomic integrity. For future CNV analysis\, we introduced the live cell ChReporter\, enabling non-invasive tracing of CNV status without compromising cell viability.
URL:https://seasevents.nmsdev7.com/event/cbe-phd-thesis-defense-comparative-analysis-of-aneuploidy-in-suspension-cancer-lines-and-solid-tumors-insights-from-single-cell-sequencing-approaches/
LOCATION:Glandt Forum\, Singh Center for Nanotechnology\, 3205 Walnut Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Dissertation or Thesis Defense
ORGANIZER;CN="Chemical and Biomolecular Engineering":MAILTO:cbemail@seas.upenn.edu
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230706T130000
DTEND;TZID=America/New_York:20230706T140000
DTSTAMP:20260404T083533
CREATED:20230626T125734Z
LAST-MODIFIED:20230626T125734Z
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SUMMARY:MEAM Ph.D. Thesis Defense: "Adding Actuation to Found Material: A Design Methodology"
DESCRIPTION:Engineers in modern society are taught to design and build structures and robots from pre-processed materials\, giving them the ability to describe the operating capacity of their structure with a high degree of certainty. From a disaster recovery and robust systems point of view\, this is a severe limitation. Rather than use processed material of known mechanical properties\, we investigate how to use ”found” material\, or preexisting material located at the deployment site\, to build and repair new and existing systems. \nWe begin by introducing a new design methodology for building with found materials. The methodology is compared with the standard engineering design process to identify the areas where a user must deviate from the standard practice. We investigate two of these deviations\, focusing on material identification and designing with that material as well as actuator integration with the found materials. The work uses experimental results to validate the actuator integration\, using both wood and ice as structural bases. \nWe review current research in the field of found materials and self-replication before presenting our work. Our contributions include a design methodology for using found material\, techniques to design structures from found material\, and actuator integration with ice and wood. We summarize these techniques through the construction of a variety of robots and structures including StickBot\, a flexible robotic system; IceBot\, a ground-based rover vehicle from ice; and an ice arm capable of cutting blocks of ice into arm segments for future use.
URL:https://seasevents.nmsdev7.com/event/meam-ph-d-thesis-defense-adding-actuation-to-found-material-a-design-methodology/
LOCATION:Levine 307\, 3330 Walnut Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Doctoral,Dissertation or Thesis Defense
ORGANIZER;CN="Mechanical Engineering and Applied Mechanics":MAILTO:meam@seas.upenn.edu
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230707T140000
DTEND;TZID=America/New_York:20230707T160000
DTSTAMP:20260404T083533
CREATED:20230621T170312Z
LAST-MODIFIED:20230621T170312Z
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SUMMARY:BE Doctoral Dissertation Defense: "In Situ and In Vivo Roles of Focal Adhesion Kinase in Tendon Development and Mechanotransduction" (Thomas Leahy)
DESCRIPTION:The Department of Bioengineering at the University of Pennsylvania and Dr. Louis Soslowsky are pleased to announce the Doctoral Dissertation Defense of Thomas Leahy.\n\nTitle:  “In Situ and In Vivo Roles of Focal Adhesion Kinase in Tendon Development and Mechanotransduction”\n\nDate: July 7\, 2023\nTime: 2:00PM\nLocation: CRB Austrian Auditorium \nZoom link\n\n\n\nThe public is welcome to attend.
URL:https://seasevents.nmsdev7.com/event/be-doctoral-dissertation-defense-in-situ-and-in-vivo-roles-of-focal-adhesion-kinase-in-tendon-development-and-mechanotransduction-thomas-leahy/
LOCATION:CRB Auditorium\, 415 Curie Boulevard\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Doctoral,Graduate,Student,Dissertation or Thesis Defense
ORGANIZER;CN="Bioengineering":MAILTO:be@seas.upenn.edu
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