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DTSTART;TZID=America/New_York:20210830T100000
DTEND;TZID=America/New_York:20210830T120000
DTSTAMP:20260406T184805
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SUMMARY:BE Doctoral Dissertation: "Biophysical dynamics of RGS-LOV proteins as systems for light-induced membrane recruitment" (Ivan Kuznetsov)
DESCRIPTION:The Department of Bioengineering at the University of Pennsylvania and \nDr. Brian Chow are pleased to announce the Doctoral Dissertation Defense of Ivan Kuznetsov. \nTitle: Biophysical dynamics of RGS-LOV proteins as systems for light-induced membrane recruitment \nDate: August 30\, 2021 \nTime: 10:00 AM \nLocation: Levine 307 and via zoom at the link below: \n\nhttps://upenn.zoom.us/j/93272141232?pwd=TWRMb2V5Wmg3Mk92aFlCcjk5cFM4UT09 \nAbstract: \nLight–oxygen–voltage sensitive (LOV) domains represent a ubiquitous family of blue-light photoreceptors. Recently\, we reported BcLOV4\, a LOV protein from B. cinerea\, which demonstrates a light-induced protein-lipid interaction with the plasma membrane. Previous work demonstrated preliminary characterization of BcLOV4 but stopped short of demonstrating its applications as an optogenetic tool. Here\, we report a 3D non-linear finite element model of the cell-wide spatiotemporal dynamics of BcLOV4 membrane recruitment. Inputs were data from single cells unique in morphology and initial absolute protein concentration\, as opposed to fitting an idealized cell to population data. All necessary BcLOV4 biophysical parameters were measured with recombinant protein or in HEK cells. The model outperforms existing (2D and/or linear) approaches and recapitulates observed complexities\, including cell-geometric effects on recruitment efficiency and inter-instrument diffractive effects. It also highlights underappreciated determinants of signaling magnitude\, contrast\, and spatial confinement – such as the nonlinearity introduced by finite membrane-binding sites\, outsized role of rebinding kinetics\, and impact of excitation volume on the signaling impulse response. By capturing both intrinsic biophysical contributions of the optogenetic tools and extrinsic contributions of the optical hardware\, this framework improves understanding of how to spatiotemporally shape signaling.\nThe biophysical and computational study of BcLOV4 suggest that it has great utility as a generalizable modality for optogenetic tool development. We leverage this to construct a multitude of BcLOV4-based tools\, focusing primarily on Rho GTPases\, specifically Rac1 and RhoA. We demonstrate that these tools can generate physiologically relevant downstream signaling\, including cell motility and\, in the case of RhoA\, YAP-TEAD-dependent transcriptional activity. This work sets the groundwork for a BcLOV4-based optogenetic toolkit for accurate dissection of mechanotransduction.
URL:https://seasevents.nmsdev7.com/event/be-doctoral-dissertation-biophysical-dynamics-of-rgs-lov-proteins-as-systems-for-light-induced-membrane-recruitment-ivan-kuznetsov_/
LOCATION:Room 307\, Levine Hall\, 3330 Walnut Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Doctoral,Graduate,Dissertation or Thesis Defense
ORGANIZER;CN="Bioengineering":MAILTO:be@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210830T120000
DTEND;TZID=America/New_York:20210830T123000
DTSTAMP:20260406T184805
CREATED:20210813T135440Z
LAST-MODIFIED:20210813T135440Z
UID:10006852-1630324800-1630326600@seasevents.nmsdev7.com
SUMMARY:PSOC Webinar: Kuangzheng (Peter) Zhu
DESCRIPTION:Zoom Meeting Waiting Room (email discher@seas for entry) \n\nhttps://upenn.zoom.us/j/95100409935?pwd=aGZjdkpYd3V4UU1qMkU5S1RiY3QvUT09\n\nMeeting ID: 951 0040 9935\nPasscode: 330227\n\nPSOC@Penn Summer Webinars 2021 \nContact manu@seas.upenn.edu with any questions
URL:https://seasevents.nmsdev7.com/event/psoc-webinar-kuangzheng-peter-zhu/
LOCATION:https://upenn.zoom.us/j/96715197752
CATEGORIES:Seminar,Doctoral,Graduate,Student
ORGANIZER;CN="PSOC":MAILTO:manu@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210831T120000
DTEND;TZID=America/New_York:20210831T160000
DTSTAMP:20260406T184805
CREATED:20210824T180018Z
LAST-MODIFIED:20210824T180018Z
UID:10006861-1630411200-1630425600@seasevents.nmsdev7.com
SUMMARY:ODEI Spotlight: SAC Fall Activities Fair
DESCRIPTION:This is an opportunity to get to know more about the many undergraduate student organizations that exist at Penn. In addition to the in-person events being hosted 8/31-9/2\, groups will be available to connect virtually from 6-8pm these same days via PennClubs.com.
URL:https://seasevents.nmsdev7.com/event/odei-spotlight-sac-fall-activities-fair/
LOCATION:PA
CATEGORIES:Diversity, Equity and Inclusion
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210901T120000
DTEND;TZID=America/New_York:20210901T160000
DTSTAMP:20260406T184805
CREATED:20210824T180242Z
LAST-MODIFIED:20210824T180242Z
UID:10006862-1630497600-1630512000@seasevents.nmsdev7.com
SUMMARY:ODEI Spotlight: SAC Fall Activities Fair Day 2
DESCRIPTION:This is an opportunity to get to know more about the many undergraduate student organizations that exist at Penn. In addition to the in-person events being hosted 8/31-9/2 on College Green\, groups will be available to connect virtually from 6-8pm these same days via PennClubs.com.
URL:https://seasevents.nmsdev7.com/event/odei-spotlight-sac-fall-activities-fair-day-2/
LOCATION:PA
CATEGORIES:Diversity, Equity and Inclusion
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210901T130000
DTEND;TZID=America/New_York:20210901T150000
DTSTAMP:20260406T184805
CREATED:20210826T144323Z
LAST-MODIFIED:20210826T144323Z
UID:10006869-1630501200-1630508400@seasevents.nmsdev7.com
SUMMARY:BE Doctoral Dissertation: "Adaptation of Maternal Skeletal Mechano-responsiveness\, Osteocyte Microenvironment\, and Bone Marrow Adipocytes in Response to Reproduction and Lactation" (Yihan Li)
DESCRIPTION:The Department of Bioengineering at the University of Pennsylvania and Dr. X. Sherry Liu are pleased to announce the Doctoral Dissertation Defense of Yihan Li.\n\nTitle: “Adaptation of Maternal Skeletal Mechano-responsiveness\, Osteocyte Microenvironment\, and Bone Marrow Adipocytes in Response to Reproduction and Lactation”\n\nDate: September 1\, 2021\nTime: 1:00 PM\nThe public is welcome to attend via the Zoom link below:\n https://upenn.zoom.us/j/7602733549
URL:https://seasevents.nmsdev7.com/event/be-doctoral-dissertation-adaptation-of-maternal-skeletal-mechano-responsiveness-osteocyte-microenvironment-and-bone-marrow-adipocytes-in-response-to-reproduction-and-lactation-yihan-li/
LOCATION:https://upenn.zoom.us/j/96715197752
CATEGORIES:Doctoral,Graduate,Dissertation or Thesis Defense
ORGANIZER;CN="Bioengineering":MAILTO:be@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210901T160000
DTEND;TZID=America/New_York:20210901T170000
DTSTAMP:20260406T184805
CREATED:20210810T191958Z
LAST-MODIFIED:20210810T191958Z
UID:10006844-1630512000-1630515600@seasevents.nmsdev7.com
SUMMARY:MSE Thesis Defense: "An In Situ Study of Resistance Degradation and Switching of Bulk Yttria-Stabilized Zirconia and Strontium Titanate Single Crystals"
DESCRIPTION:
URL:https://seasevents.nmsdev7.com/event/mse-thesis-defense-an-in-situ-study-of-resistance-degradation-and-switching-of-bulk-yttria-stabilized-zirconia-and-strontium-titanate-single-crystals/
LOCATION:PA
ORGANIZER;CN="Materials Science and Engineering":MAILTO:johnruss@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210902T120000
DTEND;TZID=America/New_York:20210902T160000
DTSTAMP:20260406T184805
CREATED:20210824T180341Z
LAST-MODIFIED:20210824T180341Z
UID:10006863-1630584000-1630598400@seasevents.nmsdev7.com
SUMMARY:ODEI Spotlight: SAC Fall Activities Fair Day 3
DESCRIPTION:This is an opportunity to get to know more about the many undergraduate student organizations that exist at Penn. In addition to the in-person events being hosted 8/31-9/2 on College Green\, groups will be available to connect virtually from 6-8pm these same days via PennClubs.com.
URL:https://seasevents.nmsdev7.com/event/odei-spotlight-sac-fall-activities-fair-day-3/
LOCATION:PA
CATEGORIES:Diversity, Equity and Inclusion
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210902T130000
DTEND;TZID=America/New_York:20210902T140000
DTSTAMP:20260406T184805
CREATED:20210831T141031Z
LAST-MODIFIED:20210831T141031Z
UID:10006872-1630587600-1630591200@seasevents.nmsdev7.com
SUMMARY:BE Doctoral Dissertation: "From '-omics' to biomarkers and mechanisms in Parkinson's disease: Growth hormone receptor and GPNMB" (Maria E. Diaz Ortiz)
DESCRIPTION:The Department of Bioengineering at the University of Pennsylvania and Dr. Alice S. Chen-Plotkin are pleased to announce the Doctoral Dissertation Defense of Maria E. Diaz Ortiz.\n \nTitle: From ‘-omics’ to biomarkers and mechanisms in Parkinson’s disease: Growth hormone receptor and GPNMB\nDate/Time: Thursday\, September 2nd from 1-2 PM EST\nZoom Link: https://us02web.zoom.us/j/83054658861?pwd=NWVIUWI5TjMxQ1dxSm9aSTVWZ1hldz09
URL:https://seasevents.nmsdev7.com/event/be-doctoral-dissertation-from-omics-to-biomarkers-and-mechanisms-in-parkinsons-disease-growth-hormone-receptor-and-gpnmb-maria-e-diaz-ortiz/
LOCATION:https://upenn.zoom.us/j/96715197752
CATEGORIES:Doctoral,Graduate,Dissertation or Thesis Defense
ORGANIZER;CN="Bioengineering":MAILTO:be@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210902T153000
DTEND;TZID=America/New_York:20210902T163000
DTSTAMP:20260406T184805
CREATED:20210707T142326Z
LAST-MODIFIED:20210707T142326Z
UID:10006821-1630596600-1630600200@seasevents.nmsdev7.com
SUMMARY:BE Seminar: "Synthetic Biochemistry: Engineering Molecules and Pathways for Precision Medicine" (Michael Lin)
DESCRIPTION:Update 9/2/21: Unfortunately due to the flooding in Philadelphia we will not be able to hold this seminar on campus. Check your email for the zoom link or contact ksas@seas.upenn.edu. \nThe most effective medicines are those that target the earliest causes of disease\, rather than later manifestations. Engineering of biomolecules is a promising but underexplored approach to precisely detecting or targeting disease causes. I will present our work to develop a novel approach to treating cancer by detecting the signaling abnormalities that give rise to cancer. Interestingly\, this effort involves biomolecular engineering at multiple scales: proteins\, pathways\, and viruses. I will also discuss how our work has translated serenditously to developing treatments for SARSCoV2.
URL:https://seasevents.nmsdev7.com/event/be-seminar-michael-lin/
LOCATION:Moore 216\, 200 S. 33rd Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Seminar
ORGANIZER;CN="Bioengineering":MAILTO:be@seas.upenn.edu
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