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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20201019T120000
DTEND;TZID=America/New_York:20201019T130000
DTSTAMP:20260407T131609
CREATED:20200908T165948Z
LAST-MODIFIED:20200908T165948Z
UID:10006478-1603108800-1603112400@seasevents.nmsdev7.com
SUMMARY:PSOC Webinar: “A three dimensional extracellular matrix supports organoid phenotype by reducing cortical actin tension to maintain endoplasmic reticulum function” (FuiBoon Kai)
DESCRIPTION:“A three dimensional extracellular matrix supports organoid phenotype by reducing cortical actin tension to maintain endoplasmic reticulum function” \nPhysical Sciences in Oncology Center PSOC@Penn \nFall 2020 Webinar Series Mondays @ Noon (EST) \nFor webinar links\, please contact manu@seas.upenn.edu
URL:https://seasevents.nmsdev7.com/event/psoc-webinar-a-three-dimensional-extracellular-matrix-supports-organoid-phenotype-by-reducing-cortical-actin-tension-to-maintain-endoplasmic-reticulum-function-fuiboon-kai/
LOCATION:PA
CATEGORIES:Seminar
ORGANIZER;CN="PSOC":MAILTO:manu@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20201020T103000
DTEND;TZID=America/New_York:20201020T120000
DTSTAMP:20260407T131609
CREATED:20200908T131425Z
LAST-MODIFIED:20200908T131425Z
UID:10006475-1603189800-1603195200@seasevents.nmsdev7.com
SUMMARY:MEAM Seminar: "Engineering Solutions for Tough Problems in Trauma: From Occlusion Balloons to Decision-Support"
DESCRIPTION:Acute hemorrhage and hemorrhagic shock result in approximately 60\,000 annual deaths in the United States. The vast majority of these deaths are in severely injured patients\, but experts in trauma care believe many of these deaths can actually be prevented. Efforts focused on injury prevention and pre-emptive intervention have produced some improvements in survival. However\, for those who sustain severe injuries\, a range of engineering solutions could mitigate the risk of death from hemorrhage. \nIn this talk\, I will review the current epidemiology of acute hemorrhage and our understanding of hemorrhagic shock. I will then explore several recent innovations designed to stop acute hemorrhage and guide teams in real-time management: balloon aortic occlusion and hemorrhage decision support. These innovations will be discussed in the context of the regulatory hurdles that must be navigated to bring these and other similar innovations to the bedside.
URL:https://seasevents.nmsdev7.com/event/meam-seminar-engineering-solutions-for-tough-problems-in-trauma-from-occlusion-balloons-to-decision-support/
LOCATION:Zoom – Email MEAM for Link\, peterlit@seas.upenn.edu
CATEGORIES:Seminar
ORGANIZER;CN="Mechanical Engineering and Applied Mechanics":MAILTO:meam@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20201020T150000
DTEND;TZID=America/New_York:20201020T160000
DTSTAMP:20260407T131609
CREATED:20201007T185556Z
LAST-MODIFIED:20201007T185556Z
UID:10006521-1603206000-1603209600@seasevents.nmsdev7.com
SUMMARY:CIS Seminar: "Theoretical Reflections on Quantum Supremacy"
DESCRIPTION:The recent demonstration of quantum supremacy by Google is a first step towards the era of small to medium scale quantum computers. In this talk I will explain what the experiment accomplished and the theoretical work it is based on\, as well as what it did not accomplish and the many theoretical and practical challenges that remain. I will also describe recent breakthroughs in the design of protocols for the testing and benchmarking of quantum computers\, a task that has deep computational and philosophical implications. Specifically\, this leads to protocols for scalable and verifiable quantum supremacy\, certifiable quantum random generation and verification of quantum computation.
URL:https://seasevents.nmsdev7.com/event/cis-seminar-theoretical-reflections-on-quantum-supremacy/
LOCATION:Zoom – Email CIS for link\, cherylh@cis.upenn.edu
ORGANIZER;CN="Computer and Information Science":MAILTO:cherylh@cis.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20201021T120000
DTEND;TZID=America/New_York:20201021T130000
DTSTAMP:20260407T131609
CREATED:20200902T125018Z
LAST-MODIFIED:20200902T125018Z
UID:10006469-1603281600-1603285200@seasevents.nmsdev7.com
SUMMARY:PICS Alumni Spotlight: "Whelton Miller"
DESCRIPTION:The PICS alumni Spotlight is an opportunity for students to learn from and network with alumni.
URL:https://seasevents.nmsdev7.com/event/pics-alumni-spotlight-whelton-miller/
LOCATION:Zoom – Email CIS for link\, cherylh@cis.upenn.edu
CATEGORIES:Alumni
ORGANIZER;CN="Penn Institute for Computational Science (PICS)":MAILTO:dkparks@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20201021T150000
DTEND;TZID=America/New_York:20201021T160000
DTSTAMP:20260407T131609
CREATED:20200916T235445Z
LAST-MODIFIED:20200916T235445Z
UID:10006501-1603292400-1603296000@seasevents.nmsdev7.com
SUMMARY:CBE Seminar: "Engineering Pathways Across Biological Barriers"
DESCRIPTION:Abstract \nEngineering pathways across biological barriers is entering a new era with the rapid advancement of computational resources. My research group focuses on developing multi-scale simulation methods to elucidate the interfacial phenomena associated with biological barriers that play a role in life-threatening diseases\, such as Alzheimer’s\, cancer\, and chronic infections. Our goal is to influence this experimentally-dominated research field by providing mechanistic\, structural\, and molecular insights into the barrier functions that were computationally unattainable prior to our work. In past few years\, we have made breakthroughs in three research domains: elucidated the molecular architecture of the blood-brain barrier and developed strategies to enhance the barrier’s permeability for treatment of the neurodegenerative diseases; developed telodendrimer-based nanocarriers for efficient delivery of approved anticancer drugs for treatment of solid tumors; and designed an online computational platform to screen libraries of small molecules for their permeability across bacterial membranes\, and determine their use as antibiotics for treatment of chronic infections. All three research domains have ties with experimental groups to ensure the validity of our research findings. In my talk\, I will elaborate on our computational methods\, present the key results\, and provide a perspective on the long-term research goals of the group.
URL:https://seasevents.nmsdev7.com/event/cbe-seminar-engineering-pathways-across-biological-barriers/
LOCATION:Zoom – Email CBE for link
CATEGORIES:Seminar,Doctoral,Graduate,Student,Master's
ORGANIZER;CN="Chemical and Biomolecular Engineering":MAILTO:cbemail@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20201022T104500
DTEND;TZID=America/New_York:20201022T114500
DTSTAMP:20260407T131609
CREATED:20200828T153817Z
LAST-MODIFIED:20200828T153817Z
UID:10006456-1603363500-1603367100@seasevents.nmsdev7.com
SUMMARY:MSE Seminar: "Polymer Informatics: Current Status & Critical Next Steps"
DESCRIPTION:The Materials Genome Initiative (MGI) has heralded a sea change in the philosophy of materials design. In an increasing number of applications\, the successful deployment of novel materials has benefited from the use of computational\, experimental and informatics methodologies. Here\, we describe the role played by computational and experimental data generation and capture\, polymer fingerprinting\, machine-learning based property prediction models\, and algorithms for designing polymers meeting target property requirements. These efforts have culminated in the creation of an online Polymer Informatics platform (https://www.polymergenome.org) to guide ongoing and future polymer discovery and design [1-3]. Challenges that remain will be examined\, and systematic steps that may be taken to extend the applicability of such informatics efforts to a wide range of technological domains will be discussed. These include strategies to deal with the data bottleneck\, new methods to represent polymer morphology and processing conditions\, and the applicability of emerging AI algorithms for materials design.
URL:https://seasevents.nmsdev7.com/event/mse-seminar-polymer-informatics-current-status-critical-next-steps/
LOCATION:PA
ORGANIZER;CN="Materials Science and Engineering":MAILTO:johnruss@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20201022T110000
DTEND;TZID=America/New_York:20201022T120000
DTSTAMP:20260407T131609
CREATED:20201020T162006Z
LAST-MODIFIED:20201020T162006Z
UID:10006528-1603364400-1603368000@seasevents.nmsdev7.com
SUMMARY:ESE Seminar: "New Tools for Better Understanding Social Networks"
DESCRIPTION:We shall examine in our talk concepts and tools for the analysis of social networks. We shall present in particular YouTube and Twitter. For YouTube\, we point at shortcomings in ways to measure audience retention and propose new concepts to better quantify desirable properties. We then present a geo-linguistic analysis of Twitter based on daily periodograms and use these to study the evolution of languages as seen in Twitter.
URL:https://seasevents.nmsdev7.com/event/ese-seminar-new-tools-for-better-understanding-social-networks/
LOCATION:Zoom – Email ESE for Link jbatter@seas.upenn.edu
CATEGORIES:Seminar,Faculty,Colloquium,Graduate,Undergraduate
ORGANIZER;CN="Electrical and Systems Engineering":MAILTO:eseevents@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20201022T150000
DTEND;TZID=America/New_York:20201022T160000
DTSTAMP:20260407T131609
CREATED:20200709T141640Z
LAST-MODIFIED:20200709T141640Z
UID:10006439-1603378800-1603382400@seasevents.nmsdev7.com
SUMMARY:BE Seminar: "High-throughput Screening of a Combinatorial CAR Co-stimulatory Domain Library" (Kyle Daniels)
DESCRIPTION:This event will be held virtually on zoom. Check email for zoom link or email ksas@seas.upenn.edu. \nCAR T cells—T cells engineered to express a chimeric antigen receptor that redirects their function to a specific antigen—have proven to be an effective therapy for certain B cell cancers\, but many issues remain in order to apply CAR T cells to a broader range of cancers. The activity of CAR T cells can be  modulated by varying their co-stimulatory domains. Most CARs use co-stimulatory domains from natural proteins such as 41BB or CD28\, each of which contains motifs that recruit unique signaling molecules and elicit a corresponding T cell response. One strategy to achieve increased control over T cell function is to engineer synthetic co-stimulatory domains composed of novel combinations of motifs from natural co-stimulatory proteins. We constructed libraries of CARs containing synthetic co-stimulatory domains and screened these library in primary human T cells for the ability to promote proliferation\, degranulation\, and memory formation. The results of the screens give insights into how signaling motifs dictate cell function and offer clues on how to engineer co-stimulatory domains that promote desired CAR T cell functions.
URL:https://seasevents.nmsdev7.com/event/be-seminar-2/
LOCATION:PA
CATEGORIES:Seminar
ORGANIZER;CN="Bioengineering":MAILTO:be@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20201023T120000
DTEND;TZID=America/New_York:20201023T130000
DTSTAMP:20260407T131609
CREATED:20201015T183605Z
LAST-MODIFIED:20201015T183605Z
UID:10006524-1603454400-1603458000@seasevents.nmsdev7.com
SUMMARY:SIG Seminar: "Physics-based Animation at Pixar"
DESCRIPTION:Pixar’s films rely heavily on physically simulated effects such as the motion of hairs\, cloth\, and water\, to cite a few. Whereas physical accuracy is of paramount importance in engineering applications\, the most important aspects of feature film productions are directability and speed. In this talk\, I’ll survey our recent work in this area\, including robust hyperelastic materials model for volume simulation and high-performance physically-based sculpting techniques.
URL:https://seasevents.nmsdev7.com/event/sig-seminar-physics-based-animation-at-pixar/
LOCATION:PA
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20201023T140000
DTEND;TZID=America/New_York:20201023T150000
DTSTAMP:20260407T131609
CREATED:20200916T125335Z
LAST-MODIFIED:20200916T125335Z
UID:10006499-1603461600-1603465200@seasevents.nmsdev7.com
SUMMARY:PICS Colloquium: "Data-driven model reduction and multiscale modal decomposition for complex chaotic systems"
DESCRIPTION:Many complex nonequilibrium systems\, including turbulent flows\, are characterized by chaotic dynamics\, a large number of degrees of freedom\, and hierarchical\, multiscale structure in space and time. In two vignettes\, we describe some recent work aimed at developing and applying machine learning and data science tools for systems displaying these characteristics. \nThe first vignette builds on the idea that while partial differential equations are formally infinite- dimensional\, the presence of energy dissipation drives the long-time dynamics onto a finite-dimensional invariant manifold sometimes called an inertial manifold (IM).  We describe a data-driven framework to represent chaotic dynamics on this manifold and illustrate it with data from simulations of the Kuramoto-Sivashinsky equation. A hybrid method combining linear and nonlinear (neural-network) dimension reduction transforms between coordinates in the full state space and on the IM. Additional neural networks predict time evolution on the IM; this can be done in either the discrete-time (difference equation) or continuous-time (ordinary differential equation) setting. The formalism accounts for translation invariance and energy conservation\, and substantially outperforms linear dimension reduction\, reproducing very well key dynamic and statistical features of the attractor. \nThe second vignette addresses how to represent flow or other fields with multiscale structure. We describe a method\, inspired by wavelet analysis\, that adaptively decomposes a dataset into an hierarchy of structures (specifically orthogonal basis vectors) localized in scale and space: a “data-driven wavelet decomposition”. This decomposition reflects the inherent structure of the dataset it acts on. In particular\, when applied to turbulent flow data\, it reveals spatially localized\, self-similar\, hierarchical structures. It is important emphasize that self-similarity is not built into the analysis\, rather\, it emerges from the data. This approach is a starting point for the characterization of localized hierarchical turbulent structures that we may think of as the building blocks of turbulence. It will also find application to other systems\, such as atmospheres\, oceans\, biological tissues\, active matter and many others\, that display multiscale spatiotemporal structure. \n  \n 
URL:https://seasevents.nmsdev7.com/event/pics-colloquium-data-driven-model-reduction-and-multiscale-modal-decomposition-for-complex-chaotic-systems/
LOCATION:PA
CATEGORIES:Colloquium
ORGANIZER;CN="Penn Institute for Computational Science (PICS)":MAILTO:dkparks@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20201023T140000
DTEND;TZID=America/New_York:20201023T150000
DTSTAMP:20260407T131609
CREATED:20201016T130532Z
LAST-MODIFIED:20201016T130532Z
UID:10006526-1603461600-1603465200@seasevents.nmsdev7.com
SUMMARY:PICS Seminar: "Simulating solids like fluids:  A fully Eulerian approach to fluid-structure interaction"
DESCRIPTION:Abstract: Fluids and solids tend to be addressed using distinct computational perspectives.  Solid deformation is most commonly simulated with Lagrangian finite-element methods\, whereas fluid flow is amenable to Eulerian-frame approaches such as finite difference and finite volume methods.  Problems that mix fluid and solid behaviors simultaneously present interesting numerical challenges.   Here we focus on fluid-structure interaction (FSI) problems\, and discuss an emerging method called the Reference Map Technique\, which allows us to simulate deformable solids on a fixed Eulerian grid.  The key is to store and update the reference map field on the grid\, which tracks the inverse motion.  Using this technique to represent the solid phase\, we can solve all phases of an FSI problem on a single fixed grid using fast update procedures very similar to those used in two-phase Navier-Stokes fluid simulations.   Various solid constitutive behaviors can be used\, such as nonlinear elasticity and plasticity.  Systems of many submerged and interacting solids can be simulated\, and\, by activating the solids internally\, we can simulate systems of “soft swimmers”.  Incompressibility and rigidity constraints can be applied in all phases by adopting Eulerian projection approaches commonly used in CFD.  The addition of the reference map field to the grid also presents certain benefits when computing level-set interface advection\, including a procedure to guarantee mass conservation. \n 
URL:https://seasevents.nmsdev7.com/event/pics-seminar-simulating-solids-like-fluids-a-fully-eulerian-approach-to-fluid-structure-interaction/
LOCATION:PA
CATEGORIES:Seminar
ORGANIZER;CN="Penn Institute for Computational Science (PICS)":MAILTO:dkparks@seas.upenn.edu
END:VEVENT
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