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DTSTART;TZID=America/New_York:20200127T130000
DTEND;TZID=America/New_York:20200127T150000
DTSTAMP:20260408T030609
CREATED:20200122T214621Z
LAST-MODIFIED:20200122T214621Z
UID:10006388-1580130000-1580137200@seasevents.nmsdev7.com
SUMMARY:CBE Dissertation: "DNA Mediated Particle Adhesion"
DESCRIPTION:Advisor: John Crocker\, PhD; Committee Members: Talid Sinno\, PhD; Scott Diamond\, PhD; and Daniel Hammer\, PhD
URL:https://seasevents.nmsdev7.com/event/cbe-dissertation-dna-mediated-particle-adhesion/
LOCATION:Raisler Lounge (Room 225)\, Towne Building\, 220 South 33rd Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Dissertation or Thesis Defense
ORGANIZER;CN="Chemical and Biomolecular Engineering":MAILTO:cbemail@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200128T103000
DTEND;TZID=America/New_York:20200128T120000
DTSTAMP:20260408T030609
CREATED:20200108T212102Z
LAST-MODIFIED:20200108T212102Z
UID:10006361-1580207400-1580212800@seasevents.nmsdev7.com
SUMMARY:MEAM Seminar: "Liquid Crystal Elastomers"
DESCRIPTION:Liquid crystal elastomers are rubbery solids with liquid crystal mesogens incorporated into their main chains. They display an isotropic to nematic phase transformation accompanied by a large spontaneous deformation. This in turn leads to rich variety of phenomena including ultra-soft behavior\, stripe domains\, shape-morphing etc. Further\, when made as slender structures\, the structural instability of slender structures and the material instabilities of liquid crystal elastomers combine and compete in interesting ways. This talk will provide an introduction to these materials and provide examples from contemporary research about opportunities these materials present.
URL:https://seasevents.nmsdev7.com/event/meam-seminar-liquid-crystal-elastomers/
LOCATION:Wu and Chen Auditorium (Room 101)\, Levine Hall\, 3330 Walnut Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Seminar
ORGANIZER;CN="Mechanical Engineering and Applied Mechanics":MAILTO:meam@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200128T120000
DTEND;TZID=America/New_York:20200128T130000
DTSTAMP:20260408T030609
CREATED:20200121T211501Z
LAST-MODIFIED:20200121T211501Z
UID:10006385-1580212800-1580216400@seasevents.nmsdev7.com
SUMMARY:MEAM Doctoral Dissertation Defense: "Applications of a Double-stranded Elastic Rod Model to DNA"
DESCRIPTION:In the first part of the presentation\, we discuss a double-stranded elastic rod (birod) model and apply it to study allosteric interactions between two ligands on DNA. Next\, we combine the birod model with statistical mechanics and use it to study the temperature-induced strand separation in dsDNA. \nAllosteric interaction between two ligands on DNA is quantified by measuring the change in free energy of the DNA complex (DNA + two ligands) as a function of the distance between the binding sites for two ligands. We show that trends in the interaction energy of two ligands binding to DNA can be explained using the birod model which accounts for the helical shape of DNA\, elastic deformation of strands and base-pairs\, and the stacking energy due to perturbations in position and orientation of the bases caused by the binding of ligands. The model predicts that the allosteric interaction energy between two ligands decays exponentially with the distance between them and oscillates with the periodicity of the double helix\, which by appropriate parameter fitting is shown to quantitatively match with the experimental measurements. Our model predicts an identical trend (exponentially decaying sinusoid) in the perturbation of groove width produced by the binding of a single ligand—consistent with the published results from molecular simulations. Our analysis provides a new framework to understand allosteric interactions in DNA and can be extended to other rod-like macromolecules whose elasticity plays a key role in their biological functions. \nIn the next part of the presentation\, we combine statistical mechanics with continuum mechanics to predict the mechanical response of DNA molecules. We observe that the external force and torque driven microstructure evolution in DNA leads to force-extension curves that exhibit strong signatures of first-order phase transitions. The effects of the electrostatic interactions on the mechanical-response predicted from the model resolve some important counter-intuitive experimental observations. Next\, we focus on one such structural transition—temperature-driven disintegration of dsDNA into two single strands\, known as DNA melting. We illustrate how the continuum mechanics of birod coupled with statistical mechanics can be used to study the micromechanics of DNA melting. We note that a nonlinear asymmetric interaction between the outer strands leads to a sudden and highly cooperative melting transition. The model enables us to couple the effect of tensile force on the melting temperature\, which to the author’s knowledge is the first mechanics-based attempt to do so. The results from the models\, after suitably choosing the parameter values\, agree with multiple experiments reported in the literature and they generate new falsifiable predictions that can be experimentally tested.
URL:https://seasevents.nmsdev7.com/event/meam-doctoral-dissertation-defense-applications-of-a-double-stranded-elastic-rod-model-to-dna/
LOCATION:4E9\, DRLB\, 209 S. 33rd Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Seminar,Doctoral,Student,Dissertation or Thesis Defense
ORGANIZER;CN="Mechanical Engineering and Applied Mechanics":MAILTO:meam@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200129T150000
DTEND;TZID=America/New_York:20200129T160000
DTSTAMP:20260408T030609
CREATED:20191219T202102Z
LAST-MODIFIED:20191219T202102Z
UID:10006351-1580310000-1580313600@seasevents.nmsdev7.com
SUMMARY:Britton Chance Distinguished Lecture: "Regenerative Immunology: The Role of Technology Translation in Guiding Discovery"
DESCRIPTION:Abstract: \nBiomaterial implants have a long history in the clinic\, but regenerative biomaterials and regenerative medicine therapies\, in general\, have been slow to reach patients. Clinical translation provides a unique and critical opportunity to investigate the key therapeutic drivers of technology efficacy in people. Careful evaluation of clinical outcomes and reevaluation of design parameters is central to improving research and technology development. A key outcome of our clinical translation experiences in orthopedics and plastic surgery was the unexpected discovery of adaptive immune cells around synthetic implants. We are now working to understand the role of the immune system and cellular senescence in the biomaterial response and repair across different tissues. This new therapeutic target serves as the basis for the design of regenerative immunotherapies.
URL:https://seasevents.nmsdev7.com/event/britton-chance-distinguished-lecture-regenerative-immunology-the-role-of-technology-translation-in-guiding-discovery/
LOCATION:Wu and Chen Auditorium (Room 101)\, Levine Hall\, 3330 Walnut Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Seminar,Distinguished Lecture
ORGANIZER;CN="Chemical and Biomolecular Engineering":MAILTO:cbemail@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200130T104500
DTEND;TZID=America/New_York:20200130T114500
DTSTAMP:20260408T030609
CREATED:20200122T203601Z
LAST-MODIFIED:20200122T203601Z
UID:10006387-1580381100-1580384700@seasevents.nmsdev7.com
SUMMARY:MSE Faculty Candidate Seminar: "Structure-property relations in hybrid 2D halide perovskites"
DESCRIPTION:Two-dimensional (2D) hybrid organic-inorganic perovskites are under intense investigation due to their interesting physical properties and superior performance in thin-film based optoelectronic devices. The structural diversity embedded in the system provides a variety of parameters to target favorable properties for applications in photovoltaics (PV) and light emitting diodes (LEDs). In this talk\, Dr. Mao will focus on the structure-property relationships in 2D hybrid perovskite materials\, where large organic cations can be inserted in the structure to increase the stability and structural diversity. First\, she will describe the development of the first completed series of 2D Dion-Jacobson (DJ) hybrid halide perovskites with a general formula A’An-1PbnI3n+1 (A’ = 3-(aminomethyl)piperidinium (3AMP) or 4-(aminomethyl)piperidinium (4AMP)\, A = methylammonium (MA)). The higher layer member (n = 4) has demonstrated good performance\, with the initial power conversion efficiency (PCE) of 7.3% and increased PCE of 12.0% with formamidinium incorporation. Furthermore\, she will introduce another set of hybrid perovskite materials for solid-state lighting applications. The lead bromide-based and mixed bromide/chloride systems have exhibited white-light broad emission and a direct correlation was found between the distortion of the inorganic framework and the emission. Last\, a series of new hybrid double perovskite halide materials are developed as lead-free\, environmentally friendly alternatives. The ability to structurally manipulate 2D hybrid halides catered to the needs opens new avenues for next-generation optoelectronics.
URL:https://seasevents.nmsdev7.com/event/mse-faculty-candidate-seminar-structure-property-relations-in-hybrid-2d-halide-perovskites/
LOCATION:Auditorium\, LRSM Building\, 3231 Walnut Street\, Philadelphia\, PA\, 19104\, United States
ORGANIZER;CN="Materials Science and Engineering":MAILTO:johnruss@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200131T140000
DTEND;TZID=America/New_York:20200131T150000
DTSTAMP:20260408T030609
CREATED:20191216T195803Z
LAST-MODIFIED:20191216T195803Z
UID:10006347-1580479200-1580482800@seasevents.nmsdev7.com
SUMMARY:PICS Seminar - Dr. Yoichiro Mori of the University of Pennsylvania & the University of Minnesota
DESCRIPTION:Abstract: Mathematical Justification of Slender Body Theory \nSystems in which thin filaments interact with the surrounding fluid abound in science and engineering. The computational and analytical difficulties associated with treating thin filaments as 3D objects has led to the development of slender body theory\, in which filaments are approximated as 1D curves in a 3D fluid. In the 70-80s\, Keller\, Rubinow\, Johnson and others derived an expression for the Stokesian flow field around a thin filament given a one-dimensional force density along the center-line curve. Through the work of Shelley\, Tornberg and others\, this slender body approximation has become firmly established as an important computational tool for the study of filament dynamics in Stokes flow. An issue with slender body approximation has been that it is unclear what it is an approximation to. As is well-known\, it is not possible to specify some value along a 1D curve to solve the 3D exterior Stokes problem. What is the PDE problem that slender body approximation is approximating? Here\, we answer this question by formulating a physically natural PDE problem with non-conventional boundary conditions on the filament surface\, which incorporates the idea that the filament must maintain its integrity (velocity along filament cross sections must be constant). We prove that this PDE problem is well-posed\, and show furthermore that the slender body approximation does indeed provide an approximation to this PDE problem by proving error estimates. This is joint work with Laurel Ohm\, Will Mitchell and Dan Spirn.
URL:https://seasevents.nmsdev7.com/event/pics-seminar-with-dr-yoichiro-mori-of-the-university-of-pennsylvania-the-university-of-minnesota/
LOCATION:PICS Conference Room 534 – A Wing \, 5th Floor\, 3401 Walnut Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Seminar,Colloquium
ORGANIZER;CN="Penn Institute for Computational Science (PICS)":MAILTO:dkparks@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200131T150000
DTEND;TZID=America/New_York:20200131T170000
DTSTAMP:20260408T030609
CREATED:20200109T172444Z
LAST-MODIFIED:20200109T172444Z
UID:10006370-1580482800-1580490000@seasevents.nmsdev7.com
SUMMARY:Thesis Defense: "Multiscale Predictions of Mechanical Response and Computational Circuit Dynamics After Traumatic Brain Injury”
DESCRIPTION:The Department of Bioengineering at the University of Pennsylvania and Dr. David Meaney are pleased to announce the Doctoral Dissertation Defense of David Gabrieli. \nThis event is open to the public.
URL:https://seasevents.nmsdev7.com/event/thesis-defense-multiscale-predictions-of-mechanical-response-and-computational-circuit-dynamics-after-traumatic-brain-injury/
LOCATION:Room 337\, Towne Building\, 220 South 33rd Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Student,Dissertation or Thesis Defense
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