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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210802T120000
DTEND;TZID=America/New_York:20210802T130000
DTSTAMP:20260406T144944
CREATED:20210520T140001Z
LAST-MODIFIED:20210520T140001Z
UID:10006796-1627905600-1627909200@seasevents.nmsdev7.com
SUMMARY:PSOC Webinar: Lindsey Fernandez & Mai Wang
DESCRIPTION:Join Zoom Meeting: \nhttps://upenn.zoom.us/j/99334915941?pwd=eDRXV1lITDlySXFyRHUyUzdmRldoQT09 \nMeeting ID: 993 3491 5941 \nPasscode: 189247 \nPSOC@Penn Summer Webinars 2021 \nContact manu@seas.upenn.edu with any questions \nLindsey Fernandez 12:00-12:30 PM \nMai Wang 12:30-1:00 PM
URL:https://seasevents.nmsdev7.com/event/psoc-webinar-lindsey-fernandez-mai-wang/
LOCATION:https://upenn.zoom.us/j/96715197752
CATEGORIES:Seminar,Doctoral,Graduate,Student
ORGANIZER;CN="Bioengineering":MAILTO:be@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210802T133000
DTEND;TZID=America/New_York:20210802T153000
DTSTAMP:20260406T144944
CREATED:20210707T132644Z
LAST-MODIFIED:20210707T132644Z
UID:10006819-1627911000-1627918200@seasevents.nmsdev7.com
SUMMARY:BE Doctoral Dissertation: "Quantitative Methods for Guiding Epilepsy Surgery from Intracranial EEG" (John Bernabei)
DESCRIPTION:The Department of Bioengineering at the University of Pennsylvania and Dr. Brian Litt are pleased to announce the Doctoral Dissertation Defense of John Bernabei.\n\n \nTitle: Quantitative methods for guiding epilepsy surgery from intracranial EEG\nDate: August 2\, 2021\nTime: 1:30 PM \nLocation: 337 Towne Building\n \nThe defense will also be available via zoom at the link below:\nhttps://upenn.zoom.us/j/95425194465
URL:https://seasevents.nmsdev7.com/event/be-doctoral-dissertation-quantitative-methods-for-guiding-epilepsy-surgery-from-intracranial-eeg-john-bernabei/
LOCATION:Room 337\, Towne Building\, 220 South 33rd Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Doctoral,Graduate,Student,Dissertation or Thesis Defense
ORGANIZER;CN="Bioengineering":MAILTO:be@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210803T103000
DTEND;TZID=America/New_York:20210803T120000
DTSTAMP:20260406T144944
CREATED:20210726T195154Z
LAST-MODIFIED:20210726T195154Z
UID:10006839-1627986600-1627992000@seasevents.nmsdev7.com
SUMMARY:MEAM Seminar: "Exploiting Interface Patterning for Adhesion Control"
DESCRIPTION:Surface force-mediated adhesion\, e.g. van der Waals forces\, is critical for direct bonding of bulk solids in the absence of an adhesive layer. However\, no two surfaces are ideally flat or perfectly conformal due to surface roughness or intentional patterning. When in the adhered state\, non-zero surface tractions arise wherever the local separation of the surfaces differs from an intrinsic equilibrium separation\, for which surface tractions vanish\, hence regions of tensile and compressive loads are induced across the interface. A fundamental understanding of such imperfect adhesion is important and unlocks opportunities to control interfacial strength and toughness in various applications including MEMS/NEMS\, micro-transfer printing\, and processes to manufacture advanced 3D integrated-circuits. The aim of this work is to understand the fundamentals of direct adhesion of non-conformal surfaces by examining the interplay of (1) the intrinsic adhesive properties of traction-separation relation (TSR)\, (2) interface geometry\, and (3) elastic deformation of the adhered bulk solids. The TSR we adopted accounts for strong repulsion when the interface separation is less than the equilibrium separation\, and only the normal surface tractions were considered. The effective TSR properties\, including the effective adhesion strength and work of separation\, are determined from numerical calculations. Simple closed-form solutions are obtained when assuming rigid bulk solids. A finite element model utilizing cohesive elements in a periodic cell was constructed to study cases with non-uniform deformation in the elastic solids under pure normal separation without shear.
URL:https://seasevents.nmsdev7.com/event/meam-seminar-exploiting-interface-patterning-for-adhesion-control/
LOCATION:Zoom – Email MEAM for Link\, peterlit@seas.upenn.edu
CATEGORIES:Seminar
ORGANIZER;CN="Mechanical Engineering and Applied Mechanics":MAILTO:meam@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210803T120000
DTEND;TZID=America/New_York:20210803T130000
DTSTAMP:20260406T144944
CREATED:20210709T201412Z
LAST-MODIFIED:20210709T201412Z
UID:10006831-1627992000-1627995600@seasevents.nmsdev7.com
SUMMARY:MEAM PhD Thesis Defense: "Controlled Levitation of Nanostructured Thin Films for Sun-Powered Near-Space Flight"
DESCRIPTION:Earth’s mesosphere is the least studied part of our atmosphere. The data it contains within itself can help develop more comprehensive and accurate models of the atmosphere and can help us understand our climate better. The main challenge before scientists is the inaccessibility of this region. The pressure is not high enough for aircraft and balloons and it is too high for satellites. There are remote sensing methods as well as transient rockets to collect data\, though they are expensive and collect data for a few minutes at a time. In this thesis\, we present photophoresis or light-driven motion as an alternative flight mechanism for long-duration access to this region. \nPhotophoretic force has long been studied for micron scale particles. However\, in order to leverage photophoresis to levitate large microflyers capable of carrying useful payloads under sunlight\, the structure of microflyers need to be ultralight\, with areal densities of no more than a few g/m2. Creating a large scale structure with thicknesses that result in temperature difference and weigh only a few g/m2 is a challenge. The approach we present in this thesis is to generate photophoretic force that leverages heat transfer between gas molecules and surface molecules/structure. By altering this heat transfer on either side of a thin disc we can generate large photophoretic forces that can levitate cm-scale samples with several milligrams of payload. \nIn this work we propose and validate a predictive theoretical framework that accounts for conductive\, convective\, and radiative heat transfer and determines the temperature of illuminated thin disc microflyers as well as their lift force and payload capacity with sizes ranging from millimeters to centimeters over pressures ranging from 10 to 120 pascals. \nWe used cheap and fast methods to fabricate cm-scale thin disc microflyers with areal density of ~ 1 g/m2 and test them in vacuum and under variable light intensity. We fabricated four generations of microflyers starting by dropcasting carbon nanotubes onto thin disc-shaped mylar films. Atomic layer deposition and laser micromachining enabled stiffer continuous and porous samples to be created as well. Moreover\, we used different microfabrication techniques to improve the performance of microflyers and increase their range of operation. Lastly\, we used our validated theoretical model to predict the performance of the microflyers in upper atmosphere under natural sunlight\, and we further propose different approaches that can lead to better performance and higher payload carrying capabilities.
URL:https://seasevents.nmsdev7.com/event/meam-phd-thesis-defense-controlled-levitation-of-nanostructured-thin-films-for-sun-powered-near-space-flight/
LOCATION:Zoom – Email MEAM for Link\, peterlit@seas.upenn.edu
CATEGORIES:Doctoral,Dissertation or Thesis Defense
ORGANIZER;CN="Mechanical Engineering and Applied Mechanics":MAILTO:meam@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210806T103000
DTEND;TZID=America/New_York:20210806T120000
DTSTAMP:20260406T144944
CREATED:20210727T132132Z
LAST-MODIFIED:20210727T132132Z
UID:10006840-1628245800-1628251200@seasevents.nmsdev7.com
SUMMARY:MEAM Seminar: "A Differential Homogenization Framework for Precipitation Strengthened Metals"
DESCRIPTION:Precipitation-strengthened alloys are a commercially important class of materials because their mechanical properties can be altered by changing the microstructure through heat-treatment. Specifically\, precipitates are introduced into the bulk (matrix) material to interact with dislocations and affect their mobility. It is known that the size\, shape\, orientation and stiffness of the precipitates\, which can be altered during the age-hardening process\, have a strong influence on the alloy and its plastic behavior. In this talk\, I will discuss a differential homogenization framework that has been developed to model elasto-viscoplastic particulate composites which exhibit hardening at the local scale. The new homogenization estimates incorporate the second moments of the local hardening fields and improve on existing formulations which only take into account the first moment. First\, we’ll consider the simple case of linear viscoelasticity and show that by using differential equations instead of difference equations\, the new formulation is more robust than earlier incremental approaches and recovers exact results for certain classes of composites. Next\, we provide estimates for creeping single crystals with elastic particles and find that neglecting the elasticity of the crystal\, an assumption which is typically made\, can lead to an overestimation of the effective creep-rate. Last\, we examine the role of microstructure on the effective workhardening of precipitation-strengthened crystals. We focus on the interplay between crystallographic and morphological anisotropy and how these can reduce the overall anisotropy\, as well as how the choice of the crystal matrix(either FCC or HCP) leads to markedly different work-hardening behavior.
URL:https://seasevents.nmsdev7.com/event/meam-seminar-a-differential-homogenization-framework-for-precipitation-strengthened-metals/
LOCATION:Zoom – Email MEAM for Link\, peterlit@seas.upenn.edu
CATEGORIES:Seminar
ORGANIZER;CN="Mechanical Engineering and Applied Mechanics":MAILTO:meam@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210809T120000
DTEND;TZID=America/New_York:20210809T130000
DTSTAMP:20260406T144944
CREATED:20210520T140513Z
LAST-MODIFIED:20210520T140513Z
UID:10006797-1628510400-1628514000@seasevents.nmsdev7.com
SUMMARY:PSOC Webinar: Benjamin Emert & Kuangzheng (Peter) Zhu
DESCRIPTION:Join Zoom Meeting: \nhttps://upenn.zoom.us/j/99334915941?pwd=eDRXV1lITDlySXFyRHUyUzdmRldoQT09 \nMeeting ID: 993 3491 5941 \nPasscode: 189247 \nPSOC@Penn Summer Webinars 2021 \nContact manu@seas.upenn.edu with any questions \nBenjamin Emert 12:00-12:30 PM \nPeter Zhu 12:30-1:00 PM
URL:https://seasevents.nmsdev7.com/event/psoc-webinar-benjamin-emert-kuangzheng-peter-zhu/
LOCATION:https://upenn.zoom.us/j/96715197752
CATEGORIES:Seminar,Doctoral,Graduate,Student,Alumni
ORGANIZER;CN="PSOC":MAILTO:manu@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210810T103000
DTEND;TZID=America/New_York:20210810T120000
DTSTAMP:20260406T144944
CREATED:20210803T133708Z
LAST-MODIFIED:20210803T133708Z
UID:10006842-1628591400-1628596800@seasevents.nmsdev7.com
SUMMARY:MEAM Seminar: "Accelerated Design of Heterogeneous Materials for Improved Failure Characteristics"
DESCRIPTION:Nature provides countless examples of the use of heterogeneity to enhance the failure properties of materials. Many biological materials\, such as bone\, marine shells\, and fish scales\, are extremely resilient to fracture and failure. These often consist of regions that are highly mineralized and stiff and regions of biopolymers that are extremely soft. In practice\, combining such disparate materials in synthetic systems is fraught with difficulties\, such as poor interfacial adhesion. However\, as we show in our work\, other types of heterogeneities lead to similar enhancements to failure characteristics\, including voids (inspired by bamboo) and spatial variations in fiber orientation (inspired by many materials\, such as aorta). With the rise of 3D printing technology\, it is possible to arbitrarily place materials with spatially-varying microstructure to mimic biological materials\, ultimately with the goal of achieving comparable improvements to failure properties in synthetic materials. \nIn this talk\, I will discuss three different types of heterogeneities that can be easily introduced to enhance failure characteristics. First\, inspired by the microstructure of the Mantis shrimp club\, we show how process defects that are intrinsic to extrusion-based additive approaches (voids and weak interfaces) can be spatially arranged in a helical (Bouligand) pattern to produce complex crack patterns and enhanced energy absorption. Next\, we show how arrangements of voids (inspired by conch shells) can deflect cracks and enhance energy dissipation during fracture. Finally\, we show how spatial variations in fiber orientation (inspired by aorta) can be produced using direct ink writing (DIW)\, leading to soft composites with high toughness and fatigue threshold. \nHeterogeneities in materials\, and the 3D printing processes used to create them\, introduce a large number of parameters into the material design process\, such as infill layer angle\, fiber orientation\, void placement\, etc. Bio-inspiration provides a starting point and some basic intuition about how to design heterogeneous materials for improved failure properties\, but it cannot guarantee optimal failure properties. I will therefore conclude the talk with a discussion of the use of Bayesian optimization for the acceleration of the design of architected heterogeneous materials with optimal failure properties. This will include the use of Bayesian optimization to design optimal architectures for energy dissipation using arrangements of voids inspired by conch shells. The second example uses a multi-fidelity Bayesian optimization approach to accelerate the design of heterogeneous triangular lattices with maximal energy absorption during compressive loading.
URL:https://seasevents.nmsdev7.com/event/meam-seminar-accelerated-design-of-heterogeneous-materials-for-improved-failure-characteristics/
LOCATION:Zoom – Email MEAM for Link\, peterlit@seas.upenn.edu
CATEGORIES:Seminar
ORGANIZER;CN="Mechanical Engineering and Applied Mechanics":MAILTO:meam@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210816T120000
DTEND;TZID=America/New_York:20210816T130000
DTSTAMP:20260406T144944
CREATED:20210520T133641Z
LAST-MODIFIED:20210520T133641Z
UID:10006792-1629115200-1629118800@seasevents.nmsdev7.com
SUMMARY:PSOC Webinar: Aayush Kant & Xingyu Chen
DESCRIPTION:Zoom Meeting Waiting Room (email discher@seas for entry) \n\nhttps://upenn.zoom.us/j/95100409935?pwd=aGZjdkpYd3V4UU1qMkU5S1RiY3QvUT09\n\nMeeting ID: 951 0040 9935\nPasscode: 330227\n\nPSOC@Penn Summer Webinars 2021 \nContact manu@seas.upenn.edu with any questions \nAayush Kant 12:00-12:30 PM \nXingyu Chen 12:30-1:00 PM
URL:https://seasevents.nmsdev7.com/event/psoc-webinar-aayush-kant-xingyu-chen/
LOCATION:https://upenn.zoom.us/j/96715197752
CATEGORIES:Seminar,Doctoral,Graduate,Student,Postdoctoral
ORGANIZER;CN="PSOC":MAILTO:manu@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210817T103000
DTEND;TZID=America/New_York:20210817T120000
DTSTAMP:20260406T144944
CREATED:20210810T131149Z
LAST-MODIFIED:20210810T131149Z
UID:10006843-1629196200-1629201600@seasevents.nmsdev7.com
SUMMARY:MEAM Seminar: "Metal and Air Generate Power for Robots"
DESCRIPTION:In many cases\, the size and weight of energy storage technologies required to power robotic systems are too large or massive for a robot to carry\, leading to limited operational times and long recharging times over which the robot remains unused. Computer-free autonomous decision making based on environmental cues provides exciting alternatives to classic control systems for robots and smart materials. Although this functionality has been studied in microswimmers and active colloids where energy in the surrounding liquid is prevalent\, there are no devices that can provide sufficient power from environmental chemicals to move and steer larger scale robots and vehicles in dry environments. \nIn this talk\, I will show a new approach for powering robots and electronics by electrochemically scavenging energy from metal surfaces. This approach overcomes energy storage scaling laws by allowing robots and electronics to extract energy from large volumes of energy dense material without having to carry the material on-board. Next\, we demonstrated an environmentally controlled voltage source (ECVS) that\, when directly attached to electric motors on a vehicle\, can increase the energy available to the vehicle and provide computer-free autonomous navigation toward chemical fuels in the environment and away from hazards. The ECVS uses electrochemistry to extract power from the chemical fuels\, and the vehicle avoids hazards that reduce the output voltage or electrochemical kinetics. \nThese works present a new method to simultaneously steer and power vehicles and robots without computers by directly responding to a wide variety of chemical fields in their environment using electrochemistry.
URL:https://seasevents.nmsdev7.com/event/meam-seminar-metal-and-air-generate-power-for-robots/
LOCATION:Zoom – Email MEAM for Link\, peterlit@seas.upenn.edu
CATEGORIES:Seminar
ORGANIZER;CN="Mechanical Engineering and Applied Mechanics":MAILTO:meam@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210820T150000
DTEND;TZID=America/New_York:20210820T170000
DTSTAMP:20260406T144944
CREATED:20210723T173941Z
LAST-MODIFIED:20210723T173941Z
UID:10006836-1629471600-1629478800@seasevents.nmsdev7.com
SUMMARY:BE Doctoral Dissertation Defense: "A Computational Study of the Influence of Cortical Processes on the Olfactory Bulb" (David Kersen)
DESCRIPTION:The Department of Bioengineering at the University of Pennsylvania and Drs. Vijay Balasubramanian and Minghong Ma proudly announce the Doctoral Dissertation Defense of David Kersen.\n\nThe title is “A computational study of the influence of cortical processes on the olfactory bulb”\n\nDate: August 20\,2021\nTime: 3:00pm\n\nThe zoom link is:\nhttps://upenn.zoom.us/j/98075290445?pwd=SXlsMlNWQ1RJSkZReW80SlVNUTY3Zz09
URL:https://seasevents.nmsdev7.com/event/be-doctoral-dissertation-defense-a-computational-study-of-the-influence-of-cortical-processes-on-the-olfactory-bulb-david-kersen/
LOCATION:Room 337\, Towne Building\, 220 South 33rd Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Doctoral,Graduate,Student,Dissertation or Thesis Defense
ORGANIZER;CN="Bioengineering":MAILTO:be@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210823T120000
DTEND;TZID=America/New_York:20210823T123000
DTSTAMP:20260406T144944
CREATED:20210813T135129Z
LAST-MODIFIED:20210813T135129Z
UID:10006851-1629720000-1629721800@seasevents.nmsdev7.com
SUMMARY:PSOC Webinar: Mai Wang
DESCRIPTION:Zoom Meeting Waiting Room (email discher@seas for entry) \n\nhttps://upenn.zoom.us/j/95100409935?pwd=aGZjdkpYd3V4UU1qMkU5S1RiY3QvUT09\n\nMeeting ID: 951 0040 9935\nPasscode: 330227\n\nPSOC@Penn Summer Webinars 2021 \nContact manu@seas.upenn.edu with any questions
URL:https://seasevents.nmsdev7.com/event/psoc-webinar-mai-wang/
LOCATION:https://upenn.zoom.us/j/96715197752
CATEGORIES:Seminar,Doctoral,Graduate,Student
ORGANIZER;CN="PSOC":MAILTO:manu@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210824T103000
DTEND;TZID=America/New_York:20210824T120000
DTSTAMP:20260406T144944
CREATED:20210817T161230Z
LAST-MODIFIED:20210817T161230Z
UID:10006857-1629801000-1629806400@seasevents.nmsdev7.com
SUMMARY:MEAM Seminar: "Deep Learning and Uncertainty Quantification: Methodologies and Applications"
DESCRIPTION:Uncertainty is ubiquitous in physical and engineering science because of the lack of knowledge\, inaccuracy in measurements\, objective stochastic nature. “You cannot be certain about uncertainty”. Uncertainty quantification plays an essential role in decision making\, solutions of partial differential equations\, optimal design\, etc. However\, quantifying the uncertainty is not trivial in computational science. The difficulty of uncertainty quantifications increases dramatically with for instance\, the dimensionality of the problems\, the type of noise in the data\, the complexity of black box functions where the data is obtained (large scale simulations\, expensive experiments)\, etc. Moreover\, with the knowledge of physics\, how to quantify uncertainty with only a few numbers of data should be considered properly. \nUncertainty quantification and its interactions with deep learning is a recently emerging interdisciplinary area that leverages the power of statistical methods\, machine learning models\, numerical methods and data-driven approach to provide reliable inference for quantities of interest in natural science and engineering problems. Given the fast growth in deep learning\, probabilistic methods and the large volume of data available across different research areas (computer visions\, natural language processing\, decision making)\, we aim in taking advantage of these recent advances to propose novel methodologies to solve problems where uncertainty quantification plays important roles. \nThis talk will highlight our recent process on the interaction between deep learning and uncertainty quantifications in the aspects of methodologies and applications. On the methodology side\, solutions regarding partial differential equations (forward problems) and system identifications (inverse problems) will be discussed with robust uncertainty estimations. Active learning and data acquisition will also be covered in the presence of uncertainty. Equipped with the methodologies we have developed\, we will briefly discuss some applications of such uncertainty quantification techniques in real-world problems such as cardiac flow activation mapping\, optimal design as well as analysis for high dimensional data.
URL:https://seasevents.nmsdev7.com/event/meam-seminar-deep-learning-and-uncertainty-quantification-methodologies-and-applications/
LOCATION:Zoom – Email MEAM for Link\, peterlit@seas.upenn.edu
CATEGORIES:Seminar
ORGANIZER;CN="Mechanical Engineering and Applied Mechanics":MAILTO:meam@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210824T150000
DTEND;TZID=America/New_York:20210824T170000
DTSTAMP:20260406T144944
CREATED:20210730T183016Z
LAST-MODIFIED:20210730T183016Z
UID:10006841-1629817200-1629824400@seasevents.nmsdev7.com
SUMMARY:BE Doctoral Dissertation Defense: "Engineering Novel High-Resolution Bioelectronic Interfaces from MXene Nanomaterials" (Brendan Murphy)
DESCRIPTION:The Department if Bioengineering at the University of Pennsylvania and Drs. Brian Litt and Flavia VItale are pleased to announce the Doctoral Dissertation Defense of Brendan Murphy.\n\nTitle: Engineering Novel High-Resolution Bioelectronic Interfaces from MXene Nanomaterials\nDate: August 24\, 2021\nTime: 3:00pm\n \nThe public is welcome to attend via Zoom:\nhttps://us06web.zoom.us/j/9948619859
URL:https://seasevents.nmsdev7.com/event/be-doctoral-dissertation-defense-engineering-novel-high-resolution-bioelectronic-interfaces-from-mxene-nanomaterials-brendan-murphy/
LOCATION:https://upenn.zoom.us/j/96715197752
CATEGORIES:Doctoral,Graduate,Dissertation or Thesis Defense,Staff
ORGANIZER;CN="Bioengineering":MAILTO:be@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210828T130000
DTEND;TZID=America/New_York:20210828T140000
DTSTAMP:20260406T144944
CREATED:20210824T191532Z
LAST-MODIFIED:20210824T191532Z
UID:10006867-1630155600-1630159200@seasevents.nmsdev7.com
SUMMARY:Launching into SEAS: Underrepresented @ Penn Engineering
DESCRIPTION:Launching into SEAS: Underrepresented @ Penn Engineering \nDate: Saturday\, August 28th \nTime: 1 p.m. – 2 p.m. \nLocation: Skirkanich Hall – Berger Auditorium \nAre you eager to get involved in the SEAS community? Interested in learning more about minority student organizations? Want to meet upperclassmen and fellow engineering students? \nJoin the Underrepresented Student Advisory Board in Engineering (USABE) and the Office of Diversity\, Equity\, and Inclusion (ODEI) in an NSO preceptorial panel featuring upperclassmen from identity organizations in SEAS. Participants will gain insightful advice on navigating their first semester in SEAS and learn about resources to support their academic\, professional\, and social development. Grab-and-go lunch will be provided at the end of the event! \nRegister for the event here. Please reach out to Shriya Karam and/or Fahmida Lubna for more information.
URL:https://seasevents.nmsdev7.com/event/launching-into-seas-underrepresented-penn-engineering/
LOCATION:PA
CATEGORIES:Diversity, Equity and Inclusion
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210830T100000
DTEND;TZID=America/New_York:20210830T120000
DTSTAMP:20260406T144944
CREATED:20210826T143903Z
LAST-MODIFIED:20210826T143903Z
UID:10006868-1630317600-1630324800@seasevents.nmsdev7.com
SUMMARY:BE Doctoral Dissertation: "Biophysical dynamics of RGS-LOV proteins as systems for light-induced membrane recruitment" (Ivan Kuznetsov)
DESCRIPTION:The Department of Bioengineering at the University of Pennsylvania and \nDr. Brian Chow are pleased to announce the Doctoral Dissertation Defense of Ivan Kuznetsov. \nTitle: Biophysical dynamics of RGS-LOV proteins as systems for light-induced membrane recruitment \nDate: August 30\, 2021 \nTime: 10:00 AM \nLocation: Levine 307 and via zoom at the link below: \n\nhttps://upenn.zoom.us/j/93272141232?pwd=TWRMb2V5Wmg3Mk92aFlCcjk5cFM4UT09 \nAbstract: \nLight–oxygen–voltage sensitive (LOV) domains represent a ubiquitous family of blue-light photoreceptors. Recently\, we reported BcLOV4\, a LOV protein from B. cinerea\, which demonstrates a light-induced protein-lipid interaction with the plasma membrane. Previous work demonstrated preliminary characterization of BcLOV4 but stopped short of demonstrating its applications as an optogenetic tool. Here\, we report a 3D non-linear finite element model of the cell-wide spatiotemporal dynamics of BcLOV4 membrane recruitment. Inputs were data from single cells unique in morphology and initial absolute protein concentration\, as opposed to fitting an idealized cell to population data. All necessary BcLOV4 biophysical parameters were measured with recombinant protein or in HEK cells. The model outperforms existing (2D and/or linear) approaches and recapitulates observed complexities\, including cell-geometric effects on recruitment efficiency and inter-instrument diffractive effects. It also highlights underappreciated determinants of signaling magnitude\, contrast\, and spatial confinement – such as the nonlinearity introduced by finite membrane-binding sites\, outsized role of rebinding kinetics\, and impact of excitation volume on the signaling impulse response. By capturing both intrinsic biophysical contributions of the optogenetic tools and extrinsic contributions of the optical hardware\, this framework improves understanding of how to spatiotemporally shape signaling.\nThe biophysical and computational study of BcLOV4 suggest that it has great utility as a generalizable modality for optogenetic tool development. We leverage this to construct a multitude of BcLOV4-based tools\, focusing primarily on Rho GTPases\, specifically Rac1 and RhoA. We demonstrate that these tools can generate physiologically relevant downstream signaling\, including cell motility and\, in the case of RhoA\, YAP-TEAD-dependent transcriptional activity. This work sets the groundwork for a BcLOV4-based optogenetic toolkit for accurate dissection of mechanotransduction.
URL:https://seasevents.nmsdev7.com/event/be-doctoral-dissertation-biophysical-dynamics-of-rgs-lov-proteins-as-systems-for-light-induced-membrane-recruitment-ivan-kuznetsov_/
LOCATION:Room 307\, Levine Hall\, 3330 Walnut Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Doctoral,Graduate,Dissertation or Thesis Defense
ORGANIZER;CN="Bioengineering":MAILTO:be@seas.upenn.edu
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210830T120000
DTEND;TZID=America/New_York:20210830T123000
DTSTAMP:20260406T144944
CREATED:20210813T135440Z
LAST-MODIFIED:20210813T135440Z
UID:10006852-1630324800-1630326600@seasevents.nmsdev7.com
SUMMARY:PSOC Webinar: Kuangzheng (Peter) Zhu
DESCRIPTION:Zoom Meeting Waiting Room (email discher@seas for entry) \n\nhttps://upenn.zoom.us/j/95100409935?pwd=aGZjdkpYd3V4UU1qMkU5S1RiY3QvUT09\n\nMeeting ID: 951 0040 9935\nPasscode: 330227\n\nPSOC@Penn Summer Webinars 2021 \nContact manu@seas.upenn.edu with any questions
URL:https://seasevents.nmsdev7.com/event/psoc-webinar-kuangzheng-peter-zhu/
LOCATION:https://upenn.zoom.us/j/96715197752
CATEGORIES:Seminar,Doctoral,Graduate,Student
ORGANIZER;CN="PSOC":MAILTO:manu@seas.upenn.edu
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20210831T120000
DTEND;TZID=America/New_York:20210831T160000
DTSTAMP:20260406T144944
CREATED:20210824T180018Z
LAST-MODIFIED:20210824T180018Z
UID:10006861-1630411200-1630425600@seasevents.nmsdev7.com
SUMMARY:ODEI Spotlight: SAC Fall Activities Fair
DESCRIPTION:This is an opportunity to get to know more about the many undergraduate student organizations that exist at Penn. In addition to the in-person events being hosted 8/31-9/2\, groups will be available to connect virtually from 6-8pm these same days via PennClubs.com.
URL:https://seasevents.nmsdev7.com/event/odei-spotlight-sac-fall-activities-fair/
LOCATION:PA
CATEGORIES:Diversity, Equity and Inclusion
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