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DTSTART;TZID=America/New_York:20200504T120000
DTEND;TZID=America/New_York:20200504T130000
DTSTAMP:20260407T191624
CREATED:20200109T174742Z
LAST-MODIFIED:20200109T174742Z
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SUMMARY:PSOC Seminar Cancelled : “A physics-driven open source software ecosystem for multicellular systems biology”
DESCRIPTION:
URL:https://seasevents.nmsdev7.com/event/psoc-seminar-a-physics-driven-open-source-software-ecosystem-for-multicellular-systems-biology/
LOCATION:Room 337\, Towne Building\, 220 South 33rd Street\, Philadelphia\, PA\, 19104\, United States
ORGANIZER;CN="PSOC":MAILTO:manu@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200504T140000
DTEND;TZID=America/New_York:20200504T153000
DTSTAMP:20260407T191624
CREATED:20200429T184222Z
LAST-MODIFIED:20200429T184222Z
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SUMMARY:Virtual Joint Seminar: Open Source Multicellular Systems Modeling for Cancer (and COVID-19)
DESCRIPTION:Virtual Joint Seminar of Penn PSOC\, Bioengineering\, PICS \nFor Zoom details\, email gormley@seas.upenn.edu \nCancer and other critical human health problems are inherently multiscale: molecular-scale processes such as receptor trafficking and metabolism drive cell-scale processes such as cycling and motility. Biophysical processes like diffusion and tissue mechanics both constrain and drive single-cell behavior. Moreover\, cells communicate and coordinate through chemical and mechanical processes. All these processes are dynamically linked to drive emergent multicellular systems behaviors in healthy and diseased tissues. \nComputational models can act as “virtual laboratories” for multicellular systems biology. The ideal such laboratory should include cell and tissue biomechanics\, biotransport of multiple chemical substrates including signaling factors\, and many interacting cells. This talk presents PhysiCell (http://dx.doi.org/10.1371/journal.pcbi.1005991)\, an open source agent-based platform for 3-D multicellular systems biology. With PhysiCell\, desktop workstations can routinely simulate systems of ten or more cell-secreted chemical signals and tissue substrates\, along with 10^5 to 10^6 individual cells that grow\, divide\, die\, secrete chemical signals\, move\, exchange mechanical forces\, and remodel their tissue microenvironment. High-performance computing (HPC) resources can run tens of thousands of copies of these models to perform vast 3-D computational experiments\, and artificial intelligence (AI) techniques can help us to accelerate these investigations and analyze the simulation results. \nWe will explore PhysiCell models of two cancer problems: (1) We will investigate how tumor-parenchyma biomechanical cross-talk can lead to tumor dormancy in liver micrometastases\, and how changes in tissue mechanics (e.g.\, after an illness\, injury\, or aging) can lead to tumor “reawakening”. (2) We will explore the critical role of stochastic tumor-immune interactions in cancer immunosurveillance. We will show joint work with Argonne National Lab to explore large hypothesis and design spaces on supercomputers\, as well as very recent advances in using machine learning to accelerate these explorations while also improving model interpretation. \nWe will also present work by a growing coalition of mathematicians\, virologists\, immunologists\, pharmacologists\, and others to rapidly prototype and iteratively improve a comprehensive multiscale SARS-CoV-2 tissue simulator. The first prototype model was built and shared internationally as open source code and interactive\, cloud-hosted models in under 12 hours\, and the work was disseminated as a community-written preprint within a week. The second prototype was updated to include ACE2 receptor-driven virus endocytosis and a more modular design; the third prototype is well underway. This coalition-based approach is developing submodel components in parallel and coordination\, allowing us to rapidly advance towards a feature complete framework to drive many independent investigations that help us attack COVID-19. This project shows the potential for similar community-driven advances in cancer. Moreover\, the novel mix of cancer biologists\, immunologists\, microbiologists\, and others is fueling creative advances and new technical capabilities in multiscale tissue modeling. We anticipate that this progress will drive advances in cancer immunology\, inflammation\, and virus-driven carcinogenesis for years to come. \nPhysiCell Animation \nhttps://www.youtube.com/watch?v=nJ2urSm4ilU&authuser=0
URL:https://seasevents.nmsdev7.com/event/virtual-joint-seminar-open-source-multicellular-systems-modeling-for-cancer-and-covid-19/
LOCATION:PA
CATEGORIES:Seminar
ORGANIZER;CN="Bioengineering":MAILTO:be@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200505T130000
DTEND;TZID=America/New_York:20200505T140000
DTSTAMP:20260407T191624
CREATED:20200501T124317Z
LAST-MODIFIED:20200501T124317Z
UID:10006432-1588683600-1588687200@seasevents.nmsdev7.com
SUMMARY:BE Thesis Defense: “Design\, Synthesis\, Structural Studies\, & Applications of Synthetic Collagen Peptides”
DESCRIPTION:The Department of Bioengineering at the University of Pennsylvania and Dr. David Chenoweth are pleased to announce the Doctoral Dissertation Defense of Alexander John Kasznel. \nTo request the Zoom link\, please contact Sarah Gormley at gormley@seas.upenn.edu.
URL:https://seasevents.nmsdev7.com/event/be-thesis-defense-design-synthesis-structural-studies-applications-of-synthetic-collagen-peptides/
LOCATION:PA
CATEGORIES:Doctoral,Student,Dissertation or Thesis Defense
ORGANIZER;CN="Bioengineering":MAILTO:be@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200514T100000
DTEND;TZID=America/New_York:20200514T110000
DTSTAMP:20260407T191624
CREATED:20200511T151457Z
LAST-MODIFIED:20200511T151457Z
UID:10006433-1589450400-1589454000@seasevents.nmsdev7.com
SUMMARY:Penn Engineering Class of 2020 Doctoral Graduate Recognition
DESCRIPTION:Join us to hear a message from the Dean of Penn Engineering\, Dr. Vijay Kumar\, and view a virtual roll call of the Class of 2020 doctoral graduates\, complete with video messages from our graduates and members of the Penn Engineering faculty. The total run time of this virtual celebration is less than one hour. No elements will be broadcast live\, and the video will be available to view at your convenience once it has been made public. The link to view the virtual celebration for the doctoral graduates will be posted here on Thursday\, May 14\, at 10:00 a.m. ET.
URL:https://seasevents.nmsdev7.com/event/penn-engineering-class-of-2020-doctoral-graduate-recognition/
LOCATION:PA
CATEGORIES:Faculty,Doctoral,Graduate,Student,Commencement
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200515T100000
DTEND;TZID=America/New_York:20200515T110000
DTSTAMP:20260407T191624
CREATED:20200511T151453Z
LAST-MODIFIED:20200511T151453Z
UID:10006434-1589536800-1589540400@seasevents.nmsdev7.com
SUMMARY:Penn Engineering Class of 2020 Undergraduate and Master's Graduate Recognition
DESCRIPTION:Dean Vijay Kumar will address the Penn Engineering Class of 2020 undergraduate and master’s graduates and their loved ones. Join us to hear Dean Kumar’s address\, view student photos\, and watch congratulatory video messages submitted by students’ families and by Penn Engineering faculty and staff. Please visit this webpage to access the link to our Class of 2020 Undergraduate and Master’s Celebration. (While the link will go live on Friday\, May 15\, at 10:00 a.m. ET\, no elements will be broadcast live; please join us at your convenience. The total runtime will be less than one hour.)
URL:https://seasevents.nmsdev7.com/event/penn-engineering-class-of-2020-undergraduate-and-masters-graduate-recognition/
LOCATION:PA
CATEGORIES:Faculty,Graduate,Student,Master's,Commencement,Undergraduate
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