T cells are important to the initiation, prevention, and cure of many diseases. For example, various T cells based cancer immunotherapies have been quite effective in treating several types of cancers. However, a significant fraction of patients do not respond. A comprehensive understanding of the complexity of the T cells repertoire in health and diseases […]
The Department of Bioengineering at the University of Pennsylvania and Dr. Joel Boerckel are pleased to announce the Doctoral Dissertation Defense of Devon E. Mason. This event is open to the public.
How can science and technology help cities solve their problems? Are there common urban air, water and energy challenges for science to tackle? 10:00 am Urban Challenges with (potential) Materials Solutions Model cities of Grenoble, France, Philadelphia, USA and Seoul, Korea 1:30 pm Adoption and Adaptation of New Technologies for Urban Challenges Joshua Sperling, National […]
Curved shells, when confined, can deform to a broad assortment of large scale shapes and smaller scale wrinkling and folding patterns quite unlike what produced by their flat counterparts. The intrinsic, natural curvature of shells is the central element that allows for this rich and very interesting morphological landscape, but it is also the source […]
Materials in Practice is a seminar series where technologists who are using materials science to shape the world we live in share their secret to doing this. We hope that anyone who wants to apply the research they are doing to solve real world problems will be able to attend this Seminar Series.
The process of scientific inquiry involves observing a signal (data) and interpreting it to generate information (knowledge). For example, in electron microscopy the signal may be a diffraction pattern from which information on crystal orientation may be deduced by applying diffraction theory. Science advances both through improvements in gathering data and in techniques for extracting […]
Recently, we introduced the concept of plate mechanical metamaterials—cellular plates with carefully controlled periodic geometry and unique mechanical properties—as well as its initial realization in the form of freestanding corrugated plates made out of an ultrathin film. We used atomic layer deposition (ALD) and microfabrication techniques to make robust plates out of a single continuous […]
Abstract: Emerging networking architectures are allowing for flexible and reconfigurable packet processing at line rate both on the switch and the NIC. Despite their promising new functionality, programmable switches and NICs are not all-powerful; they have limited state, support limited types of operations, and limit per-packet computation to operate at line rate. In this talk, I […]
Abstract: Biological species routinely collaborate for their mutual benefit or compete for available resources, thereby displaying dynamic behavior that is challenging to replicate in synthetic systems. Here, we use computational modeling to design microscopic, chemically active sheets and self-propelled particles encompassing the appropriate synergistic interactions to exhibit bio-inspired “feeding”, “fleeing” and “fighting”. This design couples […]
Additive manufacturing (AM) greatly expands the design freedom and near-net shape production of metallic components across multiple length scales. However, defects arising from starting materials, processing conditions, and post-processing may significantly affect the structural integrity and operational performance of metal AM parts. This paper seeks to elucidate common defects and defect formation mechanisms encountered in […]
Advisor: John Crocker, PhD; Committee Members: Talid Sinno, PhD; Scott Diamond, PhD; and Daniel Hammer, PhD
Liquid crystal elastomers are rubbery solids with liquid crystal mesogens incorporated into their main chains. They display an isotropic to nematic phase transformation accompanied by a large spontaneous deformation. This in turn leads to rich variety of phenomena including ultra-soft behavior, stripe domains, shape-morphing etc. Further, when made as slender structures, the structural instability of […]
In the first part of the presentation, we discuss a double-stranded elastic rod (birod) model and apply it to study allosteric interactions between two ligands on DNA. Next, we combine the birod model with statistical mechanics and use it to study the temperature-induced strand separation in dsDNA. Allosteric interaction between two ligands on DNA is […]
Abstract: Biomaterial implants have a long history in the clinic, but regenerative biomaterials and regenerative medicine therapies, in general, have been slow to reach patients. Clinical translation provides a unique and critical opportunity to investigate the key therapeutic drivers of technology efficacy in people. Careful evaluation of clinical outcomes and reevaluation of design parameters is […]
Two-dimensional (2D) hybrid organic-inorganic perovskites are under intense investigation due to their interesting physical properties and superior performance in thin-film based optoelectronic devices. The structural diversity embedded in the system provides a variety of parameters to target favorable properties for applications in photovoltaics (PV) and light emitting diodes (LEDs). In this talk, Dr. Mao will […]
Abstract: Mathematical Justification of Slender Body Theory Systems in which thin filaments interact with the surrounding fluid abound in science and engineering. The computational and analytical difficulties associated with treating thin filaments as 3D objects has led to the development of slender body theory, in which filaments are approximated as 1D curves in a 3D […]
The Department of Bioengineering at the University of Pennsylvania and Dr. David Meaney are pleased to announce the Doctoral Dissertation Defense of David Gabrieli. This event is open to the public.
