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DTSTART;TZID=America/New_York:20190709T103000
DTEND;TZID=America/New_York:20190709T113000
DTSTAMP:20260408T151244
CREATED:20190708T195150Z
LAST-MODIFIED:20190708T195150Z
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SUMMARY:BE Seminar: Next Generation Orthobiologics:  Advanced Growth Factor and Biomaterials Engineering
DESCRIPTION:The standard of care for augmenting surgical bone repair or regeneration remains bone graft harvested from the patient despite a lack of sufficient quantity or quality of graft in many clinical cases.  Bone morphogenetic protein (BMP) therapeutics have been successfully developed and commercially marketed as substitutes for bone graft.  Although the clinical success of BMP\, especially in spinal fusion\, is well-documented\, safety issues related to the required therapeutic dose\, sub-optimal delivery and off-label use have generated substantial controversy.  To address these issues and develop a next generation BMP product with improved efficacy and safety\, we designed a series of novel recombinant human chimeric proteins with enhanced binding affinities to key cellular receptors involved in bone formation.  In parallel\, a novel biomaterial scaffold was developed to improve the local retention time of these “designer” BMPs and reduce the risk of adverse events.  Through this combination of protein engineering and specialized biomaterial development\, large animal studies have demonstrated efficacy at substantially lower doses than those required with existing BMP products and the potential to provide a safer and more effective option for surgeons and patients.
URL:https://seasevents.nmsdev7.com/event/be-seminar-next-generation-orthobiologics-advanced-growth-factor-and-biomaterials-engineering/
LOCATION:Class of 62 Auditorium\, John Morgan Building\, 3620 Hamilton Walk\, Philadelphia\, PA\, 19104
CATEGORIES:Seminar
ORGANIZER;CN="Bioengineering":MAILTO:be@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190715T100000
DTEND;TZID=America/New_York:20190715T120000
DTSTAMP:20260408T151244
CREATED:20190702T140426Z
LAST-MODIFIED:20190702T140426Z
UID:10006235-1563184800-1563192000@seasevents.nmsdev7.com
SUMMARY:CBE Doctoral Dissertation Defense: "Alternating Multiblock Polyethylenes with Associating Groups: Self-Assembled Nanoscale Morphologies and Ion Transport"
DESCRIPTION:Thesis Committee: Karen Winey\, Advisor; Daeyeon Lee\, Robert Riggleman and Chinedum Osuji
URL:https://seasevents.nmsdev7.com/event/cbe-doctoral-dissertation-defense-alternating-multiblock-polyethylenes-with-associating-groups-self-assembled-nanoscale-morphologies-and-ion-transport/
LOCATION:Raisler Lounge (Room 225)\, Towne Building\, 220 South 33rd Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Doctoral,Student,Dissertation or Thesis Defense
ORGANIZER;CN="Chemical and Biomolecular Engineering":MAILTO:cbemail@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190715T100000
DTEND;TZID=America/New_York:20190715T120000
DTSTAMP:20260408T151244
CREATED:20190710T141943Z
LAST-MODIFIED:20190710T141943Z
UID:10006238-1563184800-1563192000@seasevents.nmsdev7.com
SUMMARY:CBE Doctoral Defense: "Alternating Multi-block Polyethylenes with Associating Groups: Self-Assembled Nanoscale Morphologies and Ion Transport"
DESCRIPTION:Committee: Karen Winey\, Advisor; Daeyeon Lee\, Robert Riggleman and Chinedum Osuji
URL:https://seasevents.nmsdev7.com/event/cbe-doctoral-defense-alternating-multi-block-polyethylenes-with-associating-groups-self-assembled-nanoscale-morphologies-and-ion-transport/
LOCATION:Raisler Lounge (Room 225)\, Towne Building\, 220 South 33rd Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Doctoral,Student,Dissertation or Thesis Defense
ORGANIZER;CN="Chemical and Biomolecular Engineering":MAILTO:cbemail@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190716T103000
DTEND;TZID=America/New_York:20190716T120000
DTSTAMP:20260408T151244
CREATED:20190705T150515Z
LAST-MODIFIED:20190705T150515Z
UID:10006236-1563273000-1563278400@seasevents.nmsdev7.com
SUMMARY:MEAM Seminar: "A Multi-Scale Homogenization Model for the Viscoplastic Response of Polar and Sea Ice"
DESCRIPTION:The rheology of polar ice evolves in response to weather and climate changes\, by modifying its microstructure. While the experimental evidence for the dependence of rheological properties on the microstructure is well documented\, there are only a few modeling efforts to capture the rheological behavior of polar ice\, mostly by fitting continuum models to the existing experimental data. However\, for the rapidly changing polar and sea ice\, we need a predictive model to forecast the behavior of polar ice in the future\, for which we might not have any experimental data. In this work\, we put forth a multi-scale homogenization model for the viscoplastic response of polar and sea ice\, by incorporating important microstructural features. \nIn the Arctic\, sea water freezes to form a layer of sea ice\, a multi-phase composite\, up to a few meters thick\, with a complex microstructure spanning several length scales. At the smaller length scales\, sea ice is a porous polycrystal with columnar grains\, with brine-air inclusions embedded inside the grains or dispersed along the grain boundaries. This work presents a multi-scale constitutive response for sea ice by idealizing it as a three-scale composite where the brine-air inclusions are embedded inside a polycrystalline matrix composed of columnar grains. The results from our model match with published experimental data\, by\, most importantly\, capturing the compressibility effects of brine-air inclusions. \nIn Antarctica ice sheets with a typical thickness of 1-3km\, as the snow accumulates on the surface of the ice sheet\, the snow beneath the top layer is densified and is eventually transformed into the ice with trapped air bubbles—bubbly ice. The size\, shape and volume fraction of these air bubbles have a profound impact on the rheological response of the ice. In addition\, bubble shape could also be used as strain-indicators in glaciers. We develop a multi-scale homogenization model for the constitutive response of bubbly-ice by treating it as a three-phase polycrystalline composite\, where pressurized bubbles are embedded inside the polycrystalline matrix. The model predicts that microstructural textures developed in response to different loading conditions significantly influence the macroscopic response.
URL:https://seasevents.nmsdev7.com/event/meam-seminar-a-multi-scale-homogenization-model-for-the-viscoplastic-response-of-polar-and-sea-ice/
LOCATION:Moore 216\, 200 S. 33rd Street\, Philadelphia\, PA\, 19104\, United States
ORGANIZER;CN="Mechanical Engineering and Applied Mechanics":MAILTO:meam@seas.upenn.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190716T140000
DTEND;TZID=America/New_York:20190716T160000
DTSTAMP:20260408T151244
CREATED:20190712T205435Z
LAST-MODIFIED:20190712T205435Z
UID:10006239-1563285600-1563292800@seasevents.nmsdev7.com
SUMMARY:CBE Doctoral Dissertation Defense: "Polymer Infiltration Under Extreme Confinement"
DESCRIPTION:Committee: Daeyeon Lee and Robert A. Riggleman\, Co-advisors; Ravi Radhakrishnan and Zahra Fakhraai
URL:https://seasevents.nmsdev7.com/event/cbe-doctoral-dissertation-defense-polymer-infiltration-under-extreme-confinement-2/
LOCATION:Greenberg Lounge (Room 114)\, Skirkanich Hall\, 210 South 33rd Street\, Philadelphia\, PA\, 19104\, United States
CATEGORIES:Doctoral,Student,Dissertation or Thesis Defense
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20190723T103000
DTEND;TZID=America/New_York:20190723T120000
DTSTAMP:20260408T151244
CREATED:20190715T134344Z
LAST-MODIFIED:20190715T134344Z
UID:10006240-1563877800-1563883200@seasevents.nmsdev7.com
SUMMARY:MEAM Seminar: "Microscale Robotic Wetware for Synthetic Biology"
DESCRIPTION:Small-scale robotic systems have emerged as promising tools to perform a wide-range of tasks in microbiology and medicine such as targeted delivery\, cell manipulation\, environmental monitoring\, and microassembly. In order to perform these tasks\, the robot must execute precise locomotion\, take measurements from its environment\, and use those measurements to make decisions. However\, unlike their macroscale counterparts\, microrobots typically lack intelligence on-board and are composed of simple microstructures which are driven using off-board hardware and software. Thus\, small-scale actuators\, sensors\, computation\, and communication modules are needed in order to develop intelligent\, fully functional microrobots. \nConcurrently with the field of microrobotics\, synthetic biology has developed tools to design microorganisms to exhibit desired behaviors (e.g. sensing\, communication\, and decision-making). This talk will highlight a new paradigm for microrobot design and fabrication. Our approach uniquely hinges on biofabrication\, or making things from living things\, in order to create programmable biohybrid robots composed of both biological and synthetic materials. We design robot architectures that enable interfaces between biological cells and hardware giving rise to robots composed of living material\, or robotic wetware. In particular\, we will discuss our development of magnetically actuated soft micro bio robots (SMBRs) composed of natural hydrogels\, which encapsulate and transport programmable living cells\, while supporting cell growth and function on-board. By encapsulating cells\, SMBRs can serve as individual cellular culture payloads or biofoundries in which cells\, DNA vectors\, and cellular byproducts are manufactured on-board and delivered to the environment. These results establish multi-functional robots that can be used as delivery vehicles for medical therapies\, assistants for microbiological experiments\, or building blocks for smart materials.
URL:https://seasevents.nmsdev7.com/event/meam-seminar-microscale-robotic-wetware-for-synthetic-biology/
LOCATION:Moore 216\, 200 S. 33rd Street\, Philadelphia\, PA\, 19104\, United States
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