CBE Doctoral Dissertation Defense: “Configuration Matters: Unveiling Cis-Regulatory Arrangement as a Mechanism of Transcriptional Fine-Tuning” (Emilia Leyes Porello)
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Towne 337
Abstract: The precise regulation of gene expression depends on coordinated enhancer-promoter (E-P) interactions, yet the principles governing how enhancer configuration influences transcription remain unclear. Classical models describe enhancers as modular and independent of orientation or relative positioning, but accumulating evidence suggests these assumptions may not hold true. To investigate this problem, systematic manipulations of enhancer […]


