CBE Doctoral Dissertation Defense: “Mechanical Confinement as a Driver of Aneuploidy in Cancer” (Steven Phan)
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Raisler Lounge (Room 225), Towne Building
220 South 33rd Street, Philadelphia, PA, United States
Abstract: Cell confinement and mechanical stress are common in solid tumors, but any impact on genetic changes remains unclear. Using chromosome reporters (ChReporters) that reveal heritable losses of chromosomes in live cells, we discover that ChReporter losses are surprisingly equivalent when cells are subjected to either mild confinement (6-10µm) or strong confinement (2µm). Strong confinement […]

