CBE PhD Dissertation Defense | “The effects of platelet signaling inhibitors on clot development under flow”
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Room 337, Towne Building
220 South 33rd Street, Philadelphia, PA, United States
Abstract: "Syk and Src family kinases (SFK) inhibitors interfere with signaling from GPVI, α2β1, αIIbβ3, and GPIb-IX-V to reduce thrombotic risk or induce bleeding episodes. Collagen-mediated clustering of platelet GPVI results in phosphorylation of SFKs such as Lyn and Fyn, and active Lyn is constitutively bound to GPVI to allow rapid signaling. During clotting under […]