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    • BE Seminar: “Probing Metabolism Across Scales” (Yihui Shen, Princeton University)

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    Raisler Lounge (Room 225), Towne Building 220 South 33rd Street, Philadelphia, PA, United States

    Metabolism supports the biosynthetic and energetic demand of all living creatures. Over decades, we have accumulated knowledge of how individual enzymes work in vitro, but we don’t have a good sense about how they work together in vivo. Thus, fundamental to our understanding of metabolic operation is the ability to measure metabolic activity in vivo. […]

    CIS Seminar: “Software Security Challenges in the Era of Modern Hardware”

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    Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

    Today’s hardware cannot keep secrets. Indeed, the past two decades have seen the discovery of a slew of attacks where an adversary exploits hardware features to leak software’s sensitive data. These attacks have shaken the foundations of computer security and caused a major disruption in the software industry. Fortunately, there has been a saving grace, namely the widespread adoption […]

    Spring 2023 GRASP on Robotics: Rodney Brooks, Robust.AI, “Academic research: exploration vs exploitation”

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    Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

    This is a hybrid event with in-person attendance in Wu and Chen and virtual attendance via Zoom. This week's presenter will be in-person as well.    ABSTRACT Intelligent action is critical in robotics, more so than much of AI where results are often mediated by humans in the loop. That said, robotics also needs to […]

    PICS Colloquium: “Building and using virtual models of the tricuspid valve toward better understanding, diagnosis, and treatment of its diseases”

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    PICS Conference Room 534 - A Wing , 5th Floor 3401 Walnut Street, Philadelphia, PA, United States

    Computer simulations have become critical elements of the medical device design and regulatory approval process. Naturally, the predictability and therefore value of such simulations depends highly on their accuracy. Especially for the design of heart valve replacements and repair technologies computer simulations have become a critical tool. While much progress has been made in modeling […]

    MEAM Seminar: “Data-Aware Computational Models for Science and Engineering”

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    Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

    In the past half-century, partial differential equation (PDE)-based computational models have emerged as indispensable for science and engineering. However, remarkable gaps still exist between state-of-the-art simulations and reality, meaning that many simulations are ineffective in supporting decision-making or design under uncertainty for complex systems (e.g., Mars landing). To bridge the gap and fulfill challenging real-world […]

    CIS Seminar: “Rethinking System Design for Expressive Cryptography”

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    Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

    Expressive cryptography, including Secure Multi-Party Computation (SMPC) and Fully Homomorphic Encryption (FHE), has the potential to enable transformative new applications, drawing significant interest from industry. Unfortunately, it is often slow and resource-intensive, making those applications difficult to realize. For example, SMPC enables multiple organizations (e.g., hospitals) to run joint computations on their data (e.g., for […]

    ASSET Seminar: Decision-Aware Learning for Global Health Supply Chains, Osbert Bastani (University of Pennsylvania)

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    Levine 307 3330 Walnut Street, Philadelphia, PA, United States

    Abstract: Machine learning algorithms are increasingly used in conjunction with optimization to guide decision making. A key challenge is aligning the machine learning loss with the decision-making loss. Existing solutions have limited flexibility and/or scale poorly to large datasets. We propose a principled decision-aware learning algorithm that uses a Taylor expansion of the optimal decision […]

    CIS Seminar: “Methods of Data Lookup with Hashing”

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    Levine 307 3330 Walnut Street, Philadelphia, PA, United States

    We will discuss methods of data lookup, with a focus on hash sets / tables, including motivation, properties, and variants. This will be in the context of a "CS 2" or data structures course. We will assume a basic familiarity with programming and comfort with implementing resizable lists; as well as knowledge of (but not […]

    CBE Seminar Series: “A New Phase of Biological Controls: A Design Framework for Programmable Synthetic Biomolecular Condensates and the Mechanisms of a Functional Liquid-Liquid Interface” (Yifan Dai, Duke University)

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    Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

    Abstract: A fundamental question in nature is how the cellular processes are organized with sequential and spatial precision in a dynamic and densely packed environment. Evidence is now mounting that biomolecular condensation, a demixing process mediated by phase separation coupled with percolation, dictates the organization principles of cellular biochemistry. From the perspective of synthetic biology, […]

    ESE PhD Thesis Defense: “Accelerating FPGA Developments from C to Bitstreams by Partial Reconfiguration”

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    Cora Ingrum Conference Room (Towne 215 - enter at Towne 211)

    Divide-and-Conquer and incremental compilation strategies are widely used in software compilations. To enable these strategies for FPGAs, this dissertation presents an open-source framework called PRflow, which can speed up the compilation times by at most an order of magnitude. PRflow supports different optimization levels to make better trade-offs among compile-time, area, and performance. -O0 (PRflow_RISCV) […]

    BE Seminar: “Programming multicellular interactions and organization using synthetic cell adhesion molecules” (Adam Stevens, UCSF)

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    Glandt Forum, Singh Center for Nanotechnology 3205 Walnut Street, Philadelphia, PA, United States

    Cell adhesion molecules (CAMs) are ubiquitous in multicellular organisms and specify precise cellular interactions in processes as diverse as tissue development and immune cell trafficking. We have generated an array of synthetic CAMs by combining orthogonal extracellular interactions with native intracellular domains. Diverse homotypic or heterotypic extracellular binding domains specify the connectivity between cells, while […]