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    • BE Seminar: “Where Do Therapeutic Antibodies Go?: A First-In-Human Journey” (Guolan Lu, Stanford)

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    Raisler Lounge (Room 225), Towne Building 220 South 33rd Street, Philadelphia, PA, United States

    Dr. Lu will introduce a fluorescence molecular imaging method to track therapeutic antibody delivery from cancer patients in vivo, down to single cells, through first-in-human clinical trials. She will present a new experimental and AI-powered analytical framework that integrates single-cell drug imaging with spatial omics to decipher drug-target-microenvironment in situ. This work establishes a foundational […]

    CIS Seminar: “Accessible Foundation Models: Systems, Algorithms, and Science”

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    Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

    The ever-increasing scale of foundation models, such as ChatGPT and AlphaFold, has revolutionized AI and science more generally. However, increasing scale also steadily raises computational barriers, blocking almost everyone from studying, adapting, or otherwise using these models for anything beyond static API queries. In this talk, I will present research that significantly lowers these barriers […]

    Spring 2024 GRASP on Robotics: Guillaume Sartoretti, National University of Singapore, “Towards Learned Cooperation at Scale in Robotic Multi-Agent Systems”

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    Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

    This is a hybrid event with in-person attendance in Wu and Chen and virtual attendance on Zoom. ABSTRACT With the recent advances in sensing, actuation, computation, and communication, the deployment of large numbers of robots is becoming a promising avenue to enable or speed up complex tasks in areas such as manufacturing, last-mile delivery, search-and-rescue, […]

    CBE Doctoral Dissertation Defense: “Controlled Deposition of Cargo-Carrying Colloids from Dispersed Liquid to Solid Surfaces” (Paradorn Rummaneethorn)

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    Towne 337

    Abstract: Great advances have been made in encapsulation of (biological) analytes at extremely high throughput via techniques such as microfluidics and/or conjugation. In parallel, analytical techniques such as mass spectrometry have advanced to analyze biochemical components of complex mixtures with high resolutions. Both capabilities are essential for enabling biology at subcellular scales; rather than engineering […]

    MEAM Seminar: “Precision Engineering in Health and Medicine via Acoustics”

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    Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

    Precision engineering stands at the forefront of catalyzing transformative advancements in health and medicine. Among various precise techniques utilizing phototactic, electric, and magnetic mechanisms, acoustic devices have captured heightened attention for their capability to facilitate contactless, label-free, and biocompatible manipulation of cells, extracellular vesicles, and organisms. Demonstrating proficiency in manipulating micro/nano-objects across a diverse spectrum, […]

    CIS Seminar: “Towards Flexible, Scalable, and Knowledgeable Generative Intelligence”

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    Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

    From language modeling to 3D vision, generative AI has revolutionized nearly every aspect of machine learning. In this talk, I will examine the limitations of the foundation behind many generative AI techniques–autoregressive models. Despite their impressive successes, these token-by-token models face various challenges, including 1). non-flexible computation during generation, 2). lack of rich inner structures […]

    ASSET Seminar: “Mathematical Foundations for Physical Agents” (Max Simchowitz, Massachusetts Institute of Technology, CSAIL)

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    Raisler Lounge (Room 225), Towne Building 220 South 33rd Street, Philadelphia, PA, United States

    ABSTRACT: From robotics to autonomous vehicles, machine learning agents deployed in the physical world (“physical agents”) promise to revolutionize endeavors ranging from manufacturing to agriculture to domestic labor. In this talk, we will develop mathematical foundations, from the ground up, for how to carry out this vision. We will begin our investigation by examining linear […]

    Spring 2024 GRASP SFI: Erik Bekkers, University of Amsterdam, “Fast, Expressive SE(n) Equivariant Networks through Weight-Sharing in Position-Orientation Space”

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    Levine 307 3330 Walnut Street, Philadelphia, PA, United States

    This will be a hybrid event with in-person attendance in Levine 307 and virtual attendance on Zoom. This week's speaker will be virtual. There will be an extended Q&A/discussion after the seminar from 4:00 PM to 4:30 PM.  ABSTRACT Based on the theory of homogeneous spaces we derive \textit{geometrically optimal edge attributes} to be used […]

    CBE Seminar: “Minimally Invasive Neuroelectronics” (Anqi Zhang, Stanford)

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    Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

    Abstract Neuroelectronic interfaces have enabled significant advances in both fundamental neuroscience research and the treatment of neurological disorders. However, current neuroelectronic devices have a clear trade-off between invasiveness and spatial resolution, and are unable to achieve seamless integration into the nervous system with cell-type specificity. In this talk, I will first introduce an ultra-small and […]

    ESE & BE Spring Seminar – “Ultra-high-throughput computational imaging: towards a trillion voxels per second”

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    Raisler Lounge (Room 225), Towne Building 220 South 33rd Street, Philadelphia, PA, United States

    Traditional biomedical imaging techniques face throughput bottlenecks that limit our ability to study complex dynamic samples like cells, organoids, tissues, and organisms. In particular, hardware-only systems have inherent physical limitations preventing the simultaneous improvement of resolution, field of view, and frame rate. In this seminar, I propose that large-scale, machine learning-accelerated computational imaging will be […]

    BE Seminar: “Endothelial cells and the promise of regeneration on demand” (Brisa Palikuqi, UCSF)

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    Raisler Lounge (Room 225), Towne Building 220 South 33rd Street, Philadelphia, PA, United States

    In this seminar, I explore the pivotal role of tissue stem cells and their microenvironment, known as the niche, in regeneration. With a focus on the endothelial cell niche, my work introduces an innovative in vitro vascularized perfusable model tailored for human tissue explants and organoids. My findings also highlight the crucial contribution of paracrine […]

    Spring 2024 GRASP on Robotics: Pietro Valdastri, University of Leeds, “Magnetic Surgical Robots: A “Fantastic Voyage” deep inside the human body”

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    Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

    This is a hybrid event with in-person attendance in Wu and Chen and virtual attendance on Zoom. ABSTRACT Magnetic fields offer the possibility of manipulating objects from a distance and are ideal for medical applications, as they penetrate human tissue without inflicting any harm on the patient. Magnetic fields can be harnessed to actuate surgical robots, […]