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    • PICS Colloquium: “Genetic testing and adverse selection”

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    PICS Conference Room 534 - A Wing , 5th Floor 3401 Walnut Street, Philadelphia, PA, United States

    Technology is dramatically driving down the cost of sequencing genetic data and increasing the quality of predictions made with this data. A standard concern is that these predictions could impair the functioning of insurance markets, either because insurers would abuse genetic information or because of adverse selection. We make three contributions. First, we develop a […]

    CBE Doctoral Dissertation Defense: “Synthesis of Enzyme-Powered Motors using Microfluidics” (Jessica O’Callaghan)

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    Levine 307 3330 Walnut Street, Philadelphia, PA, United States

    Abstract: This thesis addresses the fundamental questions surrounding the design and functional capabilities of enzyme-powered micromotors synthesized using microfluidic techniques. The research focuses on the development of these motors, made from artificial cell (protocell) scaffolds, and which seek to replicate the motion behavior of biological cells, investigating their propulsion mechanisms, motion directionality, and collective behavior. […]

    PRECISE Seminar: Image Curation for AI in Ophthalmology

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    https://upenn.zoom.us/j/93008201901

    This presentation will explore the critical process of curating medical imaging data for AI algorithm development in ophthalmology, highlighting the challenges and current limitations in data curation. It will discuss benchmark datasets, reference standards for FDA validation, and innovative strategies to enhance data availability. Attendees will gain insights into best practices and future directions in […]

    MEAM Seminar: “Harnessing Mechanobiology for Therapeutic Innovations: From Brain Tumors to Kidney Tissues”

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    Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

    Engineered, personalized tissues are transforming healthcare by accelerating clinical testing and serving as cell-based therapies. The emergence of induced pluripotent stem cells coupled with innovations in biomanufacturing and cellular engineering have rapidly advanced engineered tissue cellular and structural complexity. However, generating functional, mature tissues remains an enormous challenge. Control over biophysical forces governing development and […]

    ESE & CIS Spring Seminar – “Towards Transparent Representation Learning”

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    Raisler Lounge (Room 225), Towne Building 220 South 33rd Street, Philadelphia, PA, United States

    Machine learning models trained on vast amounts of data have achieved remarkable success across various applications. However, they also pose new challenges and risks for deployment in real-world high-stakes domains. Decisions made by deep learning models are often difficult to interpret, and the underlying mechanisms remain poorly understood. Given that deep learning models operate as […]

    CIS Seminar: “Decision Making with Internet-Scale Knowledge”

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    Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

    Machine learning models pretrained on internet data have acquired broad knowledge about the world but struggle to solve complex tasks that require extended reasoning and planning. Sequential decision making, on the other hand, has empowered AlphaGo’s superhuman performance, but lacks visual, language, and physical knowledge about the world. In this talk, I will present my […]

    ASSET Seminar: “Large Language Models in Medicine: Opportunities and Challenges” (Mark Dredze, Johns Hopkins University)

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    Raisler Lounge (Room 225), Towne Building 220 South 33rd Street, Philadelphia, PA, United States

    ABSTRACT: The rapid advance of AI driven by Large Language Models (LLMs), like ChatGPT, has led to impressive results across a range of different use cases. This has included several models developed for the medical domain which have exhibited surprising behaviors, such as answering medical questions and performing well on medical licensing exams. These results have demonstrated the coming transformation of medicine by […]

    Spring 2024 GRASP SFI: Spring Berman, Arizona State University, “Scalable Control of Distributed Robotic Systems for Environmental Sensing and Interaction”

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    Levine 307 3330 Walnut Street, Philadelphia, PA, United States

    This will be a hybrid event with in-person attendance in Levine 307 and virtual attendance on Zoom. This week's speaker will be virtual. ABSTRACT Various applications for autonomous multi-robot systems, such as disaster response, infrastructure repair, agricultural operations, contaminant cleanup, and wildfire suppression, will require these systems to act as distributed sensors, sources, and manipulators […]

    CBE Seminar: “Deep Learning-Enabled Design of Functional DNA-Binding Properties” (Cameron Glasscock, University of Washington)

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    Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

    Abstract DNA-binding proteins (DBPs) play critical roles in biology and biotechnology, and there has been considerable interest in the engineering of DBPs with new functions or altered specificities. While there has been success in reprogramming and the specificity of naturally occurring DBPs using selection methods, the computational design of new DBPs that engage with DNA […]

    MSE SEMINAR “Scalable Classical and Quantum Light Sources”

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    Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

    Classical and quantum light sources play a fundamental role in science and technology from quantum computing, to communications, manufacturing, defense, sensing, medicine, or imaging. However, scaling the power of lasers has always come at the cost of single mode operation, a scaling question that has been investigated, without success, since the invention of lasers in […]

    ESE Spring Seminar – “Structuring light to reveal the invisible”

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    Raisler Lounge (Room 225), Towne Building 220 South 33rd Street, Philadelphia, PA, United States

    From quantum physics to cosmology, researchers aim to see things which are typically invisible – be it the entanglement of two particles or infrared signatures from space. In these and various other fields, we are confronted by a common challenge: What we can see with our own eyes or observe using standard optical imaging systems […]

    BE Seminar: “Systems Immunology Approaches for Tissue Repair and Regeneration” (Andres Munoz-Rojas, Harvard)

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    Raisler Lounge (Room 225), Towne Building 220 South 33rd Street, Philadelphia, PA, United States

    The immune system uses a complex network of interacting cells that work together to regulate tissue physiology, homeostasis, and repair. In muscle, a tightly coordinated network of immunocytes and mesenchymal stromal cells (MSCs) is required for adequate skeletal muscle repair after acute injury or disease. Regulatory T cells (Tregs) are important players in regulating excessive […]