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    • CBE Seminar: “Imaging Genetics: Enhancer-mediated Dynamic Gene Control in Space and Time” (Bomyi Lim, University of Pennsylvania)

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    Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

    Abstract: Canonical models suggest that regulatory enhancers function independently of genomic distance, position, and orientation to activate the target gene. Indeed, a wide range of genomic distances and relative enhancer positions exist in endogenous contexts. However, systematic analysis of how specific enhancer-promoter configurations affect transcriptional dynamics has been limited by technical constraints. Here, we employ […]

    MEAM Ph.D. Thesis Defense: “The Role of YAP and TAZ in Regulating Load-induced Bone Adaptation and Osteocytes Mechanosensing”

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    Towne 305 220 S. 33rd Street, Philadelphia, PA, United States

    Mechanical loading is essential for skeletal growth, maintenance, and repair, yet the mechanisms that regulate bone mechanoadaptation remain incompletely understood. Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), downstream of the Hippo pathway, are emerging regulators of bone cell biology, but their in vivo role in skeletal mechanoadaptation has not been fully defined. […]

    MSE Seminar: Designing Biomaterials With Spatially Tunable Properties – Lesley Chow – Lehigh University

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    Wu & Chen Auditorium

    Biological tissues are complex materials where the spatial arrangement of multiple components (i.e., extracellular matrix, cells) is tightly linked to their function. For example, osteochondral tissues contain discrete biochemical and physical gradients across the bone-cartilage interface that are critical for functional load transfer in our articulating joints. Our lab is focused on strategies to fabricate […]

    ESE Fall Seminar – “Physics-Aware, Full-Stack Software to Accelerate Practical Quantum Computing”

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    Raisler Lounge (Room 225), Towne Building 220 South 33rd Street, Philadelphia, PA, United States

    Quantum software can be a force multiplier that can significantly shorten the timeline for utility-scale results from quantum hardware. In particular, several key research directions will help realize practical quantum advantage. Physics-aware, cross-layer optimizations will continue to yield important efficiencies to allow applications to make the most of quantum resources. Software-directed noise-aware optimization and error […]

    FOLDS seminar: Propagation-of-Chaos in Shallow Neural Networks beyond Logarithmic Time.

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    Amy Gutmann Hall, Room 414 3333 Chestnut Street, Philadelphia, United States

    Zoom link: https://upenn.zoom.us/j/98220304722 The analysis of gradient-based learning of Neural Networks remains an outstanding challenge, even for the simplest shallow architectures.  A powerful mathematical framework that has emerged over recent years lifts the optimization in the space of probability measures, and captures important empirical phenomena such as the 'blessing of overparametrization'. However, the resulting learning […]

    CBE Doctoral Dissertation Defense: “Mechanical Confinement as a Driver of Aneuploidy in Cancer” (Steven Phan)

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    Raisler Lounge (Room 225), Towne Building 220 South 33rd Street, Philadelphia, PA, United States

    Abstract: Cell confinement and mechanical stress are common in solid tumors, but any impact on genetic changes remains unclear. Using chromosome reporters (ChReporters) that reveal heritable losses of chromosomes in live cells, we discover that ChReporter losses are surprisingly equivalent when cells are subjected to either mild confinement (6-10µm) or strong confinement (2µm). Strong confinement […]

    MEAM Ph.D. Thesis Defense: “Pneumatic Actuation in Soft Robotic System”

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    CTA

    Soft robotic systems, constructed from compliant and adaptive materials, offer advantages such as safe interaction with humans, flexibility in motion, and the ability to conform to unstructured environments. These capabilities make them promising for applications in healthcare, manufacturing, and exploration. A central challenge, however, is the development of actuation strategies that are versatile, efficient, and […]

    CBE Doctoral Dissertation Defense: “Gas Encapsulating Microcapsules (GEMs)” (CK Yeh)

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    Vagelos Institute for Energy Science and Technology, Room 121 231 S 34th Street, Philadelphia, PA, United States

    Abstract: Microcapsules that can respond under hydrostatic pressure would open a new avenue of application in ultrasound- or impact-induced release of therapeutic agents. While microcapsules that are designed to release cargo under uniaxial compressive loadings have been developed, they are filled with liquid, rendering them insensitive to hydrostatic pressure. To overcome this limitation, bubbles can […]

    CBE Doctoral Dissertation Defense: “Engineering Multiphasic Processes to Enhance Droplet Microfluidics and Biofuel Conversion” (Owen Land)

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    Vagelos Institute for Energy Science and Technology, Room 121 231 S 34th Street, Philadelphia, PA, United States

    Abstract: Multiphasic processes underpin nearly every aspect of modern life; from the food we eat and the clothes we wear to the medicines that sustain us and the energy systems that power our world. This thesis presents three contributions to the advancement of multiphasic processes by developing intelligent control, scalable processing, and reactor design. First, […]

    MEAM Seminar: “Taking Advantage of Coherent Vortex Wakes: Formation Flight and High Density Tidal Energy Harvesting”

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    Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

    Wake flows - the fluid mechanical "debris" shed behind an aerodynamic body - are often characterized by unsteady, turbulent, low-momentum fluid. Usually these wakes are to be avoided, but in several situations the wake can exhibit an organized structure consisting of well-defined high energy vortices. Examples of these coherent, or structured, wakes include trailing vortex […]