CBE Doctoral Dissertation Defense: “Computational Strategies for Efficiently Sampling Conformational Changes in Solvated Macromolecules” (Akash Pallath)
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Amy Gutmann Hall, Room 414
3333 Chestnut Street, Philadelphia, United States
Abstract: Solvated macromolecules such as proteins and polymers undergo conformational changes in response to stimuli such as pressure, temperature, pH, ligand binding, and post-translational modification. These transitions are fundamental to biological function, from cellular signaling to misfolding and aggregation, and are increasingly harnessed in applications such as drug delivery, biosensing, and biomaterials design. Understanding how […]

