Communicating with the brain enables us to advance our understanding of brain function, treat disorders, restore lost function, and when combined with artificial cognitive frameworks, can push the frontier of human capabilities. Key to realizing brain communication and replicating cognition are new computer architectures– systems that directly sense and stimulate the brain, and those capable of running complex cognitive frameworks. In this talk, I will present recent work on the first brain-computer interfacing platform, SCALO, that can sense, process and stimulate neural activity from multiple regions of the brain with millisecond latency and milliwatts of power. SCALO flexibly supports many neuroscientific applications, enabling for the first time, study of brain-wide behavior and diseases. I will also share how new quantum and classical platforms are needed to accelerate cognitive neuroscience modeling, and outline an end to end design that connects such platforms with brain interfaces.