I will present two examples of this approach. In the first example, I will illustrate how Coulomb interactions across separate atomic layers pair fermions (electrons and holes) into bosons to achieve a superfluid condensate state. The second example will introduce the concept of moiré band engineering, where the interference between two atomic lattices reforms electronic band structures and creates new electronic orders. Finally, I will briefly discuss applications of local probe techniques to uncover hidden quantum properties in vdW platforms and share visions of leveraging rich interplays across atomic interfaces to create new quantum states of matter, new quantum devices, and new local measurements.