Personalized medicine as an emerging solution for health problems is leveraged by advanced manufacturing technologies. Personalized medical devices, tissue grafts, biomonitoring systems, and precision medicine are customized based on each patient’s needs and health background. However, the current manufacturing techniques are challenged when it comes to fabricating architected structures with complex designs. Additive manufacturing has been a strong tool for fabricating such architectures for tissue regenerative applications. In combination with sacrificial biomanufacturing, functional living materials are developed with 3D internal permeable macrochannels that enable nutrition transfer for prolonged cell viability. Conventional approaches for implantation of fully functional 3D printed tissue constructs require invasive surgeries, raising the need for more efficient alternative biomanufacturing technologies. Sound in vivo printing is a unique solution that enables printing tissue scaffolds deep inside the body where in lieu of open surgeries, the target organs can be reached through minimally invasive devices such as catheters to deliver biomaterials. For this purpose, focused ultrasound-triggered crosslinking is used for creating complex biostructures centimeters deep into the organs. Next-generation in vivo printing technology enables a smart biomanufacturing scheme for a wide range of functional biomaterials for applications in tissue regeneration, bioelectronics, drug delivery, etc.