In this talk, I will discuss my group’s work on fabricating micro- and nanosensing platforms for health monitoring. My group has developed novel electronic sensing modalities and has demonstrated their use for both in vitro with human clinical samples and in vivo in animals. In the first part of my talk, I will discuss sensor fabrication, characterization, and benchmarking against the gold standard, along with the role that these sensors can play in monitoring various chronic and acute inflammatory conditions. I will also discuss a new class of wirelessly powered nanobiosensors for immune monitoring. Finally, I will discuss challenges in translation of biosensing and microfluidic technologies beyond the lab, my personal experience, and potential solutions.