In structural materials engineering, we often aim to create materials that are simultaneously strong, tough and lightweight- a combination classically considered mutually exclusive. Biogenic composite materials such as bone exhibit a combination of these properties exceeding that of their constituents, a feat generally credited to their hierarchal structure, down to the nanoscale. In this talk, we will demonstrate the use of micro and nanoscales site-specific microstructural characterization and mechanical experiments to probe the strength, deformation, and fracture of human bone. We will demonstrate an in situ SEM/nanoindentor methodology, that enables 3-point bending fracture experiments with observation and measurement of crack growth and toughening behavior at nano and micrometer scales. We will discuss how expanding these nanoscale tissue experiments can enable future efforts in fundamental understanding of tissue regeneration. We will use generalized lessons learned about biogenic materials to discuss additive manufacturing of metals and explore how to leverage the unique tunability of nanoparticle functionalization and nanostructuring feedstock in metal additive manufacturing to expand the library of currently “printable” materials for potential applications ranging from biomedical to thermal.