Emerging nanotechnologies promise to enable a wide-range of next-generation applications – from energy-efficient computing to personalized healthcare. Yet many emerging nanotechnologies face substantial inherent imperfections and variations that have rendered making working systems – and therefore the next-generation applications they promise to enable – infeasible. In this talk, I will describe how by computing advances across the entire stack – from nanomaterial synthesis to new processing techniques, circuit design methodologies, architectures, and novel systems – these challenges can be overcome to realize the first large-scale and complex electronic systems leveraging beyond-silicon emerging nanotechnologies. As a case-study, I will describe the journey of transforming carbon nanotubes from an interesting scientific nanomaterial in academic labs into the foundation for realizing novel systems and applications that can impact our daily lives, such as the first beyond-silicon microprocessor for energy-efficient computing and novel diagnostic tools for rapid and accurate disease diagnostics. I will conclude by describing how these emerging nanotechnologies are currently being transferred from the “lab” to multiple commercial “fabs”, promising a new and exciting age for electronics and the systems and applications they can enable.