Conventional approaches to scientific discovery often prioritize building larger sensors, gathering more data, and scaling up computational power. In this talk, I will present a complementary perspective: extracting insights hidden in the data we already have. The key lies in using AI not as a black-box predictor, but as a tool for interpreting data through its underlying physical process.

I will demonstrate how AI, when integrated with the physics of light propagation, can serve as a computational lens to overcome fundamental limitations in fields ranging from biomedicine to astrophysics. Specifically, I will showcase two compelling applications: non-invasive imaging through scattering biological tissues, and detecting faint exoplanets against the overwhelming brightness of their host stars.

These methods represent a departure from traditional learning-based approaches that rely on fitting models to training labels and hoping for generalization. Instead, with physics-informed strategies that decode how light propagates, we can transform raw measurements into scientifically meaningful insights—without requiring costly hardware upgrades or human-annotated datasets. Finally, I will outline future directions for combining AI with physical principles, enabling us to unlock more phenomena once considered hidden and accelerating discoveries in healthcare, astronomy, and beyond.