Abstract:

Recent technical advances are leading to a rapid transformation of the chemical palette available in cells, thus making it conceivable to produce nearly any organic molecule of interest—from biofuels to biopolymers to pharmaceuticals. However, these feats require the ability to “hijack” native cellular machinery and metabolism and navigate the complexity inherent in cellular regulation. This talk will cover examples of how microbial systems and enzyme can achieve the goal of sustainable chemical production and waste valorization. Examples include rewired cells for polymer precursors, unconventional carbon utilization including plastic waste, and platform strain engineering. Throughout the talk, there will be a focus on the biological developments necessary to achieve a sustainable, circular economy.