Abstract
Advancing the synthesis of small molecules is critical to the advent of new medicines, materials, and agrochemicals. Our lab has been exploring strategies in chemical synthesis — both in reaction method development and total synthesis — that leverage modern data science techniques and robotics. This presentation will share some recent results using informatics to target novel amine-acid coupling reactions, and algorithms to streamline multistep synthesis. Chemical synthesis enabled by data science techniques and automation will be a consistent theme of the research, aiming towards a future state where medicines are invented at a rapid pace.